Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 6/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294694 | 0.89 | AURKB (0.37) | IGF1RPAK1PAK4AURKANTRK1 | |
| SCHEMBL10294699 | 0.87 | AURKA (0.45) | IGF1RAURKANTRK1AURKBGSK3B | |
| SCHEMBL10294902 | 0.86 | IGF1R (0.49) | IGF1RPAK1PAK4AURKANTRK1 | |
| SCHEMBL10294871 | 0.85 | IGF1R (0.36) | IGF1RAURKANTRK1AURKBGSK3B | |
| SCHEMBL10294912 | 0.83 | IGF1R (0.47) | IGF1RPAK1PAK4AURKANTRK1 | |
| SCHEMBL10294916 | 0.83 | PAK1 (0.37) | IGF1RPAK1AURKANTRK1AURKB | |
| SCHEMBL10294692 | 0.80 | AURKA (0.48) | IGF1RPAK1PAK4AURKANTRK1 | |
| SCHEMBL10294994 | 0.80 | AURKB (0.53) | IGF1RAURKAAURKBGSK3BSRC | |
| SCHEMBL10294997 | 0.79 | AURKB (0.46) | IGF1RPAK1PAK4AURKANTRK1 | |
| SCHEMBL10294899 | 0.78 | AURKB (0.53) | IGF1RPAK1PAK4AURKANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-07-05 | — | — | US | disclosed |
| WO-2010144359-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | ABRAXIS BIOSCIENCE, LLC (US) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CYP3A5, CYP11B2, ABCB1 | IGF1R 4230/4885PAK1 4091/4885PAK4 3960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.