SCHEMBL1029592

SCHEMBL1029592

O=P(O)(O)COCCCl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9302950 0.83 KDM4E (0.39)
SCHEMBL9301574 0.80 MEN1 (0.39)
SCHEMBL9125477 0.78
SCHEMBL25375392 0.77 TYMS (0.46)
SCHEMBL2355129 0.76 KDM4E (0.44)
SCHEMBL4341560 0.76
SCHEMBL264477 0.74
SCHEMBL8420859 0.74
SCHEMBL11298932 0.74 TYMP (0.39)
SCHEMBL264440 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109438514-A The preparation method of Aldoforwe ester 湖南方盛制药股份有限公司 2019-03-08 CN claimed
CN-109438514-A The preparation method of Aldoforwe ester 湖南方盛制药股份有限公司 2019-03-08 CN disclosed
CN-109438514-A The preparation method of Aldoforwe ester 湖南方盛制药股份有限公司 2019-03-08 CN disclosed
EP-2847201-B1 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASE INHIBITORS UNIV QUEENSLAND (AU) 2017-08-16 EP disclosed
EP-2736914-B1 METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN ALPHA-OXY PHOSPHORUS GROUP BY USING P-X COMPONENTS STRAITMARK HOLDING AG (CH) 2016-07-06 EP disclosed
EP-2665734-B1 METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN alpha-OXY PHOSPHORUS GROUP STRAITMARK HOLDING AG (CH) 2016-06-29 EP disclosed
EP-1406911-B1 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY ACAD OF SCIENCE CZECH REPUBLIC (CZ) 2016-01-06 EP disclosed
US-9200020-B2 6-oxopurine phosphoribosyltransferase inhibitors THE UNIVERSITY OF QUEENSLAND (AU) 2015-12-01 US disclosed
US-20150099722-A1 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASE INHIBITORS THE UNIVERSITY OF QUEENSLAND (AU) 2015-04-09 US disclosed
EP-2847201-A2 6-OXOPURINE PHOSPHORIBOSYLTRANSFERASE INHIBITORS The University of Queensland (AU) 2015-03-18 EP disclosed
US-20050038058-A1 Novel compounds and methods for therapy INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY 2005-02-17 US disclosed
WO-2004111064-A1 PYRIMIDINE COMPOUNDS HAVING PHOSPHONATE GROUPS AS ANTIVIRAL NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2004-12-23 WO disclosed
US-6818633-B2 Antiviral for RNA or DNA viruses such as HIV, HBV or HSV; acyclic pyrimidine nucleoside phosphonate analogues; 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine; ; alkylating the 6-hydroxypyrimidine base with a dialkyl 2-chloroethoxymethylphosphonate INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2004-11-16 US disclosed
US-6812224-B2 A FUNGICIDE, BACTERICIDE TREATING INFECTIONS IN HUMANS, ANIMALS, PLANTS AND HERBICIDE IN PLANTS JOMAA PHARMAKA GMBH (DE) 2004-11-02 US disclosed
US-6753324-B2 USED IN INFECTIONS BY VIRUSES, BACTERIA, FUNGI, AND PARASITES JOMAA HASSAN (DE) 2004-06-22 US disclosed
EP-1406911-A1 6-[2-(PHOSPHONOMETHOXY)ALKOXY]PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2004-04-14 EP disclosed
US-20030109499-A1 Novel compounds and methods for therapy INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES 2003-06-12 US disclosed
US-20030045746-A1 Phosphorous organic compounds and their use JOMAA PHARMAKA GMBH (DE) 2003-03-06 US disclosed
US-20030036533-A1 Phosphorous organic compounds and their use JOMAA PHARMAKA GMBH (DE) 2003-02-20 US disclosed
WO-2003002580-A1 6-`2-(PHOSPHONOMETHOXY)ALKOXY PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OFTHE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2003-01-09 WO disclosed