Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 1/20 | 0.68 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.68 |
| ▸ | CSF1R | P07333 | 2/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023315 | 0.90 | PDGFRB (0.75) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL8810873 | 0.87 | PDGFRB (0.68) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL16281244 | 0.86 | KDM1A (0.60) | IRAK1IRAK4CSF1RPDGFRBKDM1A | |
| SCHEMBL8815929 | 0.86 | IRAK1 (0.59) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL4359665 | 0.86 | CSF1R (0.81) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL6788900 | 0.85 | IRAK1 (0.59) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL297514 | 0.85 | ENPP1 (0.68) | IRAK1IRAK4KDM1AEGFRKDM4E | |
| SCHEMBL14417895 | 0.85 | KDM1A (0.58) | IRAK1IRAK4KDM1AEGFRKDM4E | |
| SCHEMBL4419576 | 0.85 | IRAK1 (0.60) | IRAK1IRAK4KDM1AEGFRKDM4E | |
| SCHEMBL295891 | 0.85 | ENPP1 (0.68) | IRAK1IRAK4KDM1AEGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211911-B2 | Compounds as kinase inhibitors | CHEN GUOQING PAUL (US) | 2012-07-03 | — | — | US | disclosed |
| US-20100048599-A1 | Compounds As Kinase Inhibitors | CHEN GUOQING PAUL | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048599-A1 | Compounds As Kinase Inhibitors | MAP3K1, MAP3K5, MAP3K6 | IRAK1 373/4885IRAK4 628/4885CSF1R 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.