Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 1/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | KIF5B | P33176 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810873 | 0.86 | PDGFRB (0.68) | IRAK1IRAK4MAPK1CSF1RPDGFRB | |
| SCHEMBL10296331 | 0.86 | IRAK1 (0.68) | IRAK1IRAK4MAPK1CSF1RPDGFRB | |
| SCHEMBL7145582 | 0.83 | TRPA1 (0.58) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL4023315 | 0.81 | PDGFRB (0.75) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL4359665 | 0.81 | CSF1R (0.81) | IRAK1IRAK4CSF1RPDGFRBFLT4 | |
| SCHEMBL16281244 | 0.78 | KDM1A (0.60) | IRAK1IRAK4MAPK1CSF1RPDGFRB | |
| SCHEMBL3336424 | 0.78 | PIK3CD (0.53) | IRAK1IRAK4MAPK1CSF1RPDGFRB | |
| SCHEMBL6788900 | 0.78 | IRAK1 (0.59) | IRAK1IRAK4MAPK1CSF1RPDGFRB | |
| SCHEMBL4419576 | 0.77 | IRAK1 (0.60) | IRAK1IRAK4MAPK1ABCB1EGFR | |
| SCHEMBL297514 | 0.77 | ENPP1 (0.68) | IRAK1IRAK4MAPK1EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782570-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |