SCHEMBL10299485

SCHEMBL10299485

OC(Cn1cncn1)c1ccc(Cl)cc1Cl

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2C P18825 1/20 0.59
KCNH2 Q12809 2/20 0.46
LMNA P02545 1/20 0.44
PKM P14618 1/20 0.44
TDP1 Q9NUW8 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CYP19A1 P11511 1/20 0.42
POLB P06746 2/20 0.41
MAPT P10636 2/20 0.41
ALDH1A1 P00352 2/20 0.41
HPGD P15428 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
GABRA1 P14867 1/20 0.41
TSHR P16473 1/20 0.41
GABRG2 P18507 1/20 0.41
GABRB3 P28472 1/20 0.41
KDM4E B2RXH2 2/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15927738 1.00 ADRA2C (0.59) ADRA2CKCNH2LMNAPKMTDP1
Nitric Acid SCHEMBL10833077 0.91 ADRA2C (0.51) ADRA2CKCNH2LMNAPKMTDP1
SCHEMBL10959036 0.89 ADRA2C (0.46) ADRA2CLMNAPKMTDP1MEN1
SCHEMBL10961074 0.86 POLB (0.51) ADRA2CLMNAPKMTDP1MEN1
SCHEMBL31254073 0.86 ADRA2C (0.50) ADRA2CKCNH2LMNAPKMTDP1
SCHEMBL9785351 0.86 ADRA2C (0.45) ADRA2CLMNAPKMMEN1KMT2A
SCHEMBL29622918 0.86 ADRA2C (0.45) ADRA2CLMNAPKMMEN1KMT2A
SCHEMBL10978037 0.85 CYP19A1 (0.46) ADRA2CKCNH2LMNAPKMTDP1
SCHEMBL11018513 0.85 ADRA2C (0.45) ADRA2CKCNH2LMNAPKMTDP1
SCHEMBL11182405 0.85 ADRA2C (0.40) ADRA2CMEN1KMT2ACYP19A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113954192-A Wood preservative formulation 拱木保护有限公司 2022-01-21 CN claimed
CN-113717950-A Hybridoma cell strain secreting penconazole monoclonal antibody and application thereof 江南大学 2021-11-30 CN claimed
WO-2013090995-A1 A WOOD PRESERVATIVE ARCH WOOD PROTECTION PTY LTD (AU) 2013-06-27 WO claimed
CN-102295610-B Preparation method and application of 1-aryl-2-(1,2,4-triazole-1-group) ethanol UNIV HUNAN 2013-01-23 CN claimed
CN-113717950-B Hybridoma cell strain secreting penconazole monoclonal antibody and application thereof 江南大学 2023-08-22 CN disclosed
CN-113954192-A Wood preservative formulation 拱木保护有限公司 2022-01-21 CN disclosed
CN-113717950-A Hybridoma cell strain secreting penconazole monoclonal antibody and application thereof 江南大学 2021-11-30 CN disclosed
CN-108289454-B Microorganism control agent and miticidal composition 大阪燃气化学株式会社 2021-11-09 CN disclosed
US-11028078-B2 Itraconazole analogs and use thereof THE JOHNS HOPKINS UNIVERSITY (US) 2021-06-08 US disclosed
US-20190040046-A1 ITRACONAZOLE ANALOGS AND USE THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2019-02-07 US disclosed
US-9844220-B2 Synergistic fungicidal active substance combinations FMC CORPORATION (US) 2017-12-19 US disclosed
US-9717247-B2 Synergistic fungicidal active combinations BAYER CROPSCIENCE AG (DE) 2017-08-01 US disclosed
US-4327104-A FUNGICIDES AND BACTERICIDES BAYER AKTIENGESELLSCHAFT (DE) 1982-04-27 US disclosed
EP-0000017-B1 1-(2-PHENYLETHYL)-TRIAZOLIUM SALTS, THEIR PREPARATION AND THEIR USE AS FUNGICIDES BAYER AG (DE) 1981-09-30 EP disclosed
US-4256754-A PHENYL-1,2,4-TRIAZOLE DERIVATIVE, CARBAMATE BASF AKTIENGESELLSCHAFT (DE) 1981-03-17 US disclosed
EP-0022531-A1 1-(2,4-Dichlorophenyl)-1-(2,6-dihalogenobenzylmercapto)-2-(1,2,4-triazol-1-yl)-ethanes, process for their preparation and their use as fungicides BAYER AG (DE) 1981-01-21 EP disclosed
EP-0000018-B1 METAL SALT COMPLEXES OF 1-PHENYL-2-TRIAZOLYL-ETHANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES BAYER AG (DE) 1981-01-07 EP disclosed
EP-0000017-A1 1-(2-Phenylethyl)-triazolium salts, their preparation and their use as fungicides BAYER AG (DE) 1978-12-20 EP disclosed
EP-0000018-A1 Metal salt complexes of 1-phenyl-2-triazolyl-ethane derivatives, their preparation and their use as fungicides BAYER AG (DE) 1978-12-20 EP disclosed
US-4102891-A FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1978-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190040046-A1 ITRACONAZOLE ANALOGS AND USE THEREOF SHH, GLI1, KDR ADRA2C 1400/4885KCNH2 4508/4885LMNA 4868/4885
US-11028078-B2 Itraconazole analogs and use thereof SHH, GLI1, KDR ADRA2C 1400/4885KCNH2 4508/4885LMNA 4868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.