ADRA2C

Alpha-2C adrenergic receptor · P18825 · ADRA2C on Sugi Atlas →

343,737 patent compounds predicted against ADRA2C, 240,560 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Brimonidine (SCHEMBL24670)	1.00	19/20
Dexmedetomidine (SCHEMBL26433)	1.00	11/20
Clonidine (SCHEMBL5983)	1.00	10/20
Prochlorperazine (SCHEMBL18429)	1.00	7/20
Bisantrene (SCHEMBL4773)	0.44	7/20
Amitriptyline (SCHEMBL7824)	1.00	6/20
Bisantrene (SCHEMBL7472)	0.43	6/20
Ergotamine (SCHEMBL1483)	1.00	5/20
Oxymetazoline (SCHEMBL24301)	1.00	5/20
Ergotamine (SCHEMBL8045)	0.93	5/20
Ergotamine (SCHEMBL8046)	0.93	5/20
Phenylephrine (SCHEMBL4711)	1.00	4/20
Phenylephrine (SCHEMBL4712)	1.00	4/20
Phentolamine (SCHEMBL5653)	1.00	4/20
Fenfluramine (SCHEMBL16215)	1.00	4/20
Dexfenfluramine (SCHEMBL16706)	1.00	4/20
Bromocriptine (SCHEMBL25297)	1.00	4/20
Olanzapine (SCHEMBL28763)	1.00	4/20
Phenylephrine (SCHEMBL24654)	0.96	4/20
Phenylephrine (SCHEMBL24655)	0.96	4/20

Clinical trials — most relevant to ADRA2C by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism	PHASE4	UNKNOWN
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Reversal of Acute β-Blocker Induced Bronchoconstriction	PHASE4	COMPLETED
Dexmedetomidine Versus Propofol in Vitreoretinal Surgery	PHASE4	COMPLETED
Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)	PHASE2/PHASE3	COMPLETED
Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults	PHASE3	NOT_YET_RECRUITING
Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy	PHASE3	COMPLETED
Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU	PHASE3	RECRUITING
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure	PHASE3	COMPLETED
Analgesia After Laparoscopic Cholecystectomy	PHASE2	UNKNOWN
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children	PHASE1	COMPLETED
Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation	PHASE1	ACTIVE_NOT_RECRUITING
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
Ultrasound Guided Rectus Sheath Block and Transversus Abdominis Plane Block	nan	COMPLETED
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Articaine Plus Dexmedetomidine in Supraclavicular Block	nan	UNKNOWN
Dexmedetomidine for Pain Reduction in CABG	nan	UNKNOWN
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes	nan	COMPLETED
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
Add-on Salmeterol Versus Montelukast in Arg/Arg-16 Asthmatics	nan	COMPLETED
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide	nan	COMPLETED
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.	nan	COMPLETED
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADRA2C binder may also engage these)

Protein	Name	Similarity
Q60476	—	1.000	Q60476 →
P22086	—	1.000	P22086 →
Q01337	—	1.000	Q01337 →
P34971	—	1.000	P34971 →
Q28998	—	1.000	Q28998 →
Q28838	—	0.999	Q28838 →
P18871	—	0.996	P18871 →
Q9TT96	—	0.995	Q9TT96 →
ADRA1D	Alpha-1D adrenergic receptor	0.995	landscape →
O02666	—	0.994	O02666 →
P47899	—	0.994	P47899 →
Q9TST6	—	0.994	Q9TST6 →
P79148	—	0.994	P79148 →
P23944	—	0.993	P23944 →
Q6XXX9	—	0.993	Q6XXX9 →
P22909	—	0.992	P22909 →
Q6XXY0	—	0.991	Q6XXY0 →
Q28927	—	0.991	Q28927 →
P97714	—	0.991	P97714 →
Q60474	—	0.991	Q60474 →
Q93126	—	0.991	Q93126 →
Q01338	—	0.990	Q01338 →
P18090	—	0.990	P18090 →
ADRA2A	Alpha-2A adrenergic receptor	0.989	landscape →
Q17239	—	0.989	Q17239 →
P35405	—	0.988	P35405 →
Q25322	—	0.988	Q25322 →
Q9N297	—	0.987	Q9N297 →
P26255	—	0.987	P26255 →
ADRB1	Beta-1 adrenergic receptor	0.987	landscape →