Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10306151 | 0.91 | SMYD2 (0.37) | KMT2ASMYD2GAAHTTSMN1; SMN2 | |
| SCHEMBL761862 | 0.86 | KMT2A (0.40) | KMT2AGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL762310 | 0.86 | KMT2A (0.40) | KMT2AGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL13021387 | 0.85 | KMT2A (0.39) | KMT2AGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL2243926 | 0.84 | KMT2A (0.35) | KMT2AGAAHTT | |
| SCHEMBL9939516 | 0.83 | KMT2A (0.41) | KMT2AGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL10306152 | 0.80 | GAA (0.39) | KMT2AGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL3974988 | 0.78 | KMT2A (0.43) | KMT2AGAAHTTSMN1; SMN2HSD11B1 | |
| SCHEMBL3977726 | 0.78 | KMT2A (0.43) | KMT2AGAAHTTSMN1; SMN2HSD11B1 | |
| SCHEMBL13764772 | 0.78 | KMT2A (0.43) | KMT2AGAAHTTSMN1; SMN2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211910-B2 | Tri-, tetra-substituted-3-aminopyrrolidine derivative | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090253726-A1 | TRI-, TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253726-A1 | TRI-, TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVE | AAAS, NPEPPS, TEAD4 | KMT2A 3317/4885SMYD2 4637/4885GAA 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.