NPEPPS

Puromycin-sensitive aminopeptidase · P55786 · NPEPPS on Sugi Atlas →

3,938 patent compounds predicted against NPEPPS, 2,052 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Puromycin (SCHEMBL747760)	0.64	14/20
SCHEMBL4669759	0.50	13/20
Puromycin (SCHEMBL4570)	1.00	12/20
Puromycin (SCHEMBL3042415)	1.00	12/20
Puromycin (SCHEMBL4317)	0.99	12/20
Puromycin (SCHEMBL677485)	0.99	12/20
Puromycin (SCHEMBL2348795)	0.99	12/20
Puromycin (SCHEMBL2483615)	0.99	12/20
Puromycin (SCHEMBL5067276)	0.99	12/20
Puromycin (SCHEMBL6037874)	0.99	12/20
Puromycin (SCHEMBL4030642)	0.97	12/20
Puromycin (SCHEMBL1043518)	0.94	12/20
Puromycin (SCHEMBL5789393)	0.94	12/20
SCHEMBL637768	0.87	12/20
Puromycin (SCHEMBL1359178)	0.83	12/20
SCHEMBL5566767	0.70	12/20
SCHEMBL5566769	0.70	12/20
SCHEMBL5566776	0.70	12/20
Puromycin (SCHEMBL5704567)	0.69	12/20
Hygromycin A (SCHEMBL1287900)	0.64	12/20

Clinical trials — most relevant to NPEPPS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Fluticasone and Salmeterol in Allergic Rhinitis	PHASE4	COMPLETED
Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes	PHASE3	COMPLETED
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis	PHASE2/PHASE3	RECRUITING
Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load	PHASE2/PHASE3	COMPLETED
Efficacy of Candesartan on Symptomatic Heart Failure in Treating Diabetic and Hypertensive Patients.	PHASE3	COMPLETED
Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus	PHASE2	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery	nan	COMPLETED
Ovarian Reserve and Matrix Metalloproteinases	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
DPP4 Activity, Microvascular Reactivity and Inflammation	nan	COMPLETED
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract	nan	COMPLETED
Apelin12 in Acne Vulgaris	nan	UNKNOWN
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.	nan	UNKNOWN
A Cut-off Value Study of N-terminal Brain Natriuretic Peptide （Chemiluminescence Method）	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Large-scale COVID-19 Population Screening	nan	UNKNOWN
Pharmacodynamics of CNP During Growth Hormone Treatment	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Diagnostic and Prognostic Role of Troponin and Brain Natriuretic Peptide in Pediatric Patients With Cardiomyopathy in Correlation to Echocardiography Findings	nan	UNKNOWN
Identification of Biomarkers Associated With Human Hepatocellular Carcinoma by SELDI	nan	UNKNOWN
Proteomic Profiling for Congenital Diaphragmatic Hernia	nan	UNKNOWN
Patient's Derived Organoids for Drug Screening in Glioblastoma	nan	NOT_YET_RECRUITING
Biomarkers in Urine for Children With Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria	nan	COMPLETED
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism	nan	NOT_YET_RECRUITING
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
The Effect of Monoallelic Variants in the ALPL Gene on the Natural Course of Hypophosphatasia in Russia	nan	RECRUITING
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NPEPPS binder may also engage these)

Protein	Name	Similarity
Q11011	—	0.999	Q11011 →
Q6K4E7	—	0.999	Q6K4E7 →
Q8VZH2	—	0.997	Q8VZH2 →
Q0J2B5	—	0.996	Q0J2B5 →
Q6Z6L4	—	0.994	Q6Z6L4 →
ENPEP	Glutamyl aminopeptidase	0.994	landscape →
A6NEC2	—	0.994	A6NEC2 →
Q0J5V5	—	0.993	Q0J5V5 →
P32454	—	0.992	P32454 →
Q59KZ1	—	0.991	Q59KZ1 →
P79171	—	0.989	P79171 →
Q9USX1	—	0.989	Q9USX1 →
Q9EQH2	—	0.989	Q9EQH2 →
Q9JJ22	—	0.989	Q9JJ22 →
P97449	—	0.989	P97449 →
ANPEP	Aminopeptidase N	0.989	landscape →
ERAP2	Endoplasmic reticulum aminopeptidase 2	0.989	landscape →
Q4TT88	—	0.988	Q4TT88 →
A5HUI5	—	0.988	A5HUI5 →
P15145	—	0.988	P15145 →
P37898	—	0.987	P37898 →
P15541	—	0.986	P15541 →
Q6IP81	—	0.986	Q6IP81 →
O57579	—	0.985	O57579 →
Q32LQ0	—	0.985	Q32LQ0 →
Q6C3E5	—	0.985	Q6C3E5 →
ERAP1	Endoplasmic reticulum aminopeptidase 1	0.985	landscape →
Q5B0W8	—	0.984	Q5B0W8 →
A6QPT7	—	0.983	A6QPT7 →
Q84TA3	—	0.983	Q84TA3 →