⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22363831 | 1.00 | — | — | |
| SCHEMBL17790692 | 1.00 | — | — | |
| SCHEMBL26248115 | 0.83 | KISS1R (0.46) | — | |
| SCHEMBL17590427 | 0.80 | — | — | |
| SCHEMBL10065855 | 0.80 | — | — | |
| SCHEMBL162036 | 0.80 | — | — | |
| SCHEMBL27967038 | 0.79 | — | — | |
| SCHEMBL23774879 | 0.78 | — | — | |
| SCHEMBL4330205 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL25381057 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025930-A1 | SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN | UNIVERISTY OF SOUTH CAROLINA | 2024-01-25 | — | — | US | disclosed |
| US-20230201353-A1 | SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS | NOVARTIS AG (CH) | 2023-06-29 | — | — | US | disclosed |
| US-20170283445-A1 | Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins | UNIVERSITY OF SOUTH CAROLINA | 2017-10-05 | — | — | US | disclosed |
| US-9102708-B2 | Methods for the synthesis of dicarba bridges in organic compounds | SYNGENE LIMITED (AU) | 2015-08-11 | — | — | US | disclosed |
| US-20120178666-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2012-07-12 | — | — | US | disclosed |
| US-8188217-B2 | — | — | 2012-05-29 | — | — | US | disclosed |
| US-20100036089-A1 | Methods for the Synthesis of Dicarba Bridges in Organic Compounds | MONASH UNIVERSITY (AU) | 2010-02-11 | — | — | US | disclosed |