KISS1R

KiSS-1 receptor · Q969F8 · KISS1R on Sugi Atlas →

18,738 patent compounds predicted against KISS1R, 11,636 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4197502	1.00	20/20
Hydrochloric Acid (SCHEMBL4203064)	1.00	20/20
Hydrochloric Acid (SCHEMBL4202117)	0.99	20/20
Hydrochloric Acid (SCHEMBL4200074)	0.98	20/20
Hydrochloric Acid (SCHEMBL4200350)	0.98	20/20
Hydrochloric Acid (SCHEMBL4202425)	0.98	20/20
Hydrochloric Acid (SCHEMBL4200389)	0.98	20/20
Trifluoroacetic Acid (SCHEMBL4200175)	0.90	20/20
Hydrochloric Acid (SCHEMBL4199088)	0.86	20/20
Hydrochloric Acid (SCHEMBL4200857)	0.85	20/20
Hydrochloric Acid (SCHEMBL4199974)	0.85	20/20
Hydrochloric Acid (SCHEMBL4201019)	0.83	20/20
Hydrochloric Acid (SCHEMBL4202921)	0.83	20/20
Hydrochloric Acid (SCHEMBL4200804)	0.80	20/20
SCHEMBL4197548	0.78	20/20
SCHEMBL4200184	0.78	20/20
SCHEMBL4202920	0.77	20/20
Hydrochloric Acid (SCHEMBL4202440)	0.77	20/20
Hydrochloric Acid (SCHEMBL4199220)	0.76	20/20
Hydrochloric Acid (SCHEMBL4197583)	0.76	20/20

Clinical trials — most relevant to KISS1R by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of a Liraglutide on IVF in Obese PCOS	PHASE4	COMPLETED
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
INTEnsity of ovariaN Stimulation and Embryo Quality	PHASE4	COMPLETED
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.	PHASE3	COMPLETED
Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men	PHASE3	COMPLETED
KP-10 and Insulin Secretion in Men	PHASE3	COMPLETED
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism	PHASE2	COMPLETED
Administration of Kisspeptin in Patients With Hyperprolactinemia	PHASE2	COMPLETED
Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea	PHASE2	RECRUITING
The Use of the Hormone Kisspeptin in 'in Vitro Fertilisation' (IVF) Treatment	PHASE2	COMPLETED
A Pharmacodynamic Study of Leuprorelin Gelatin-Free Formulation in Female Subjects With Uterine Fibroids.	PHASE2	COMPLETED
Kisspeptin Administration in the Adult	PHASE1	COMPLETED
Dampening the Reproductive Axis With Continuous Kisspeptin	PHASE1	COMPLETED
Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling	PHASE1	COMPLETED
Kisspeptin Administration Subcutaneously to Patients With Reproductive Disorders	PHASE1	COMPLETED
Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease	PHASE1	RECRUITING
Kisspeptin in the Evaluation of Delayed Puberty	PHASE1	COMPLETED
Neuropeptides in Human Reproduction	PHASE1	COMPLETED
Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp	PHASE1	WITHDRAWN
Follicle-Stimulating Hormone (FSH) and the Onset of Puberty	EARLY_PHASE1	COMPLETED
Association of Kisspeptin Levels With Insulin Secretion in Diabetes Mellitus	nan	COMPLETED
Physiological Role of KiSS-1/GPR54 System in the Human Ovary	nan	WITHDRAWN
Hypiend - Multicomponent Behavioral Intervention in Pre-puberal Children (Hypiend-PPC)	nan	ACTIVE_NOT_RECRUITING
Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells	nan	COMPLETED
Kisspeptin/GPR54 Pathway and Early Puberty	nan	COMPLETED
Inherited Reproductive Disorders	nan	RECRUITING
Reproductive Hormones During Sustained Administration of Kisspeptin	nan	RECRUITING
Hormonal Regulation of Puberty and Fertility	nan	COMPLETED
Progesterone Primed Ovarian Stimulation Versus GnRH Antagonist Protocols in Women With Polycystic Ovarian Syndrome	nan	COMPLETED
Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KISS1R binder may also engage these)

Protein	Name	Similarity
Q924U1	—	0.994	Q924U1 →
Q91V45	—	0.990	Q91V45 →
Q60483	—	0.987	Q60483 →
GALR2	Galanin receptor type 2	0.986	landscape →
ADRB3	Beta-3 adrenergic receptor	0.986	landscape →
Q9XT57	—	0.984	Q9XT57 →
O02662	—	0.984	O02662 →
Q9XT58	—	0.983	Q9XT58 →
Q9TST4	—	0.981	Q9TST4 →
Q28524	—	0.980	Q28524 →
P46626	—	0.980	P46626 →
P34971	—	0.980	P34971 →
Q95252	—	0.979	Q95252 →
O88626	—	0.978	O88626 →
O88853	—	0.977	O88853 →
P25962	—	0.975	P25962 →
P79148	—	0.974	P79148 →
P26255	—	0.974	P26255 →
O08726	—	0.973	O08726 →
ADRA2C	Alpha-2C adrenergic receptor	0.972	landscape →
P47899	—	0.972	P47899 →
Q28998	—	0.971	Q28998 →
O88854	—	0.971	O88854 →
Q6TLJ0	—	0.971	Q6TLJ0 →
NTSR2	Neurotensin receptor type 2	0.970	landscape →
Q9TT96	—	0.970	Q9TT96 →
DRD4	D(4) dopamine receptor	0.970	landscape →
HTR6	5-hydroxytryptamine receptor 6	0.970	landscape →
Q9TST6	—	0.969	Q9TST6 →
PRLHR	Prolactin-releasing peptide receptor	0.969	landscape →