Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | MGMT | P16455 | 2/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031242 | 0.83 | MAPT (0.73) | HRH4PDGFRBMAPTKIT | |
| SCHEMBL1030946 | 0.82 | MAP4K4 (0.47) | PDGFRBMAPTMAP4K4KITCKS1B | |
| SCHEMBL38942 | 0.80 | HRH4 (0.85) | HRH4PDGFRBADORA1PIK3CAPIK3CG | |
| SCHEMBL1920031 | 0.78 | SCD (0.47) | MAPTMAP4K4KITCKS1BSKP1 | |
| SCHEMBL978369 | 0.76 | MAP4K4 (0.46) | MAPTMAP4K4KITCKS1BSKP1 | |
| SCHEMBL655402 | 0.75 | MAP4K4 (0.46) | MAPTMAP4K4KITCKS1BSKP1 | |
| SCHEMBL20507720 | 0.74 | MAP4K4 (0.48) | MAPTMAP4K4KITCKS1BSKP1 | |
| SCHEMBL1031240 | 0.74 | KIT (0.58) | MAPTMAP4K4KITCKS1BSKP1 | |
| SCHEMBL30225432 | 0.74 | KIT (0.58) | MAPTMAP4K4KITCKS1BSKP1 | |
| SCHEMBL654787 | 0.74 | MAP4K4 (0.45) | MAPTMAP4K4KITCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067123-B1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-01-19 | — | — | EP | disclosed |
| US-6423716-B1 | Nitrogenous heterocyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-07-23 | — | — | US | disclosed |
| EP-1067123-A1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |