Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | PDE8A | O60658 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2060257 | 0.84 | CYP11B1 (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2060105 | 0.83 | PDE8A (0.55) | PDE4APDE4BPDE4CPDE4DCDK1 | |
| SCHEMBL10309723 | 0.81 | ADORA2A (0.44) | ADORA2AADORA1TMIGD3ADORA2BTLR7 | |
| SCHEMBL23764069 | 0.79 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCDK1 | |
| SCHEMBL13233224 | 0.78 | CDK1 (0.69) | PDE4APDE4BPDE4CPDE4DCDK1 | |
| SCHEMBL2060285 | 0.77 | TLR7 (0.46) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7491638 | 0.77 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL2060288 | 0.77 | CDK1 (0.58) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL6153383 | 0.76 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL23764023 | 0.76 | TLR7 (0.46) | PDE4APDE4BPDE4CPDE4DCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178743-A1 | NOVEL ADENINE COMPOUND AND USE THEREOF | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178743-A1 | NOVEL ADENINE COMPOUND AND USE THEREOF | ADORA1, HRH4, P2RY10 | PDE4A 1189/4885PDE4B 1624/4885PDE4C 2048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.