Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PDE8A | O60658 | 1/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23420269 | 0.86 | PDE4A (0.42) | TLR7PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7491638 | 0.86 | PDE4A (0.58) | TLR7PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6153383 | 0.83 | PDE4A (0.57) | TLR7PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6153440 | 0.82 | PDE4A (0.56) | TLR7PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27804178 | 0.82 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL23764385 | 0.81 | PDE8A (0.59) | TLR7PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23764021 | 0.81 | ADORA2A (0.43) | TLR7PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1146640 | 0.80 | PNP (0.40) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL21076558 | 0.80 | TLR7 (0.57) | TLR7PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23422306 | 0.80 | ADORA2A (0.43) | TLR7PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3450433-B1 | PURINE DERIVATIVES AS TLR7 INHIBITORS FOR TREATING E.G. SYSTEMIC LUPUS ERYTHEMATOSUS | SUMITOMO DAINIPPON PHARMA CO LTD (JP) | 2021-08-18 | — | — | EP | disclosed |