Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ELANE | P08246 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.33 |
| ▸ | FABP7 | O15540 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24603586 | 0.90 | ALDH1A1 (0.40) | ALDH1A1ELANELMNATSHRKMT2A | |
| SCHEMBL2028686 | 0.90 | ALDH1A1 (0.40) | ALDH1A1ELANELMNATSHRKMT2A | |
| SCHEMBL22689142 | 0.80 | ALDH1A1 (0.33) | ALDH1A1ELANETSHRCYP2D6LGALS8 | |
| SCHEMBL16062780 | 0.78 | NT5E (0.43) | ALDH1A1LMNATSHRKMT2ACYP2D6 | |
| SCHEMBL12729487 | 0.77 | CYP2D6 (0.39) | ALDH1A1LMNATSHRKMT2ACYP2D6 | |
| SCHEMBL12757246 | 0.76 | NT5E (0.37) | ALDH1A1LMNATSHRKMT2ACYP2D6 | |
| SCHEMBL28656205 | 0.76 | ALDH1A1 (0.35) | ALDH1A1TSHRKMT2AMAPK1LGALS8 | |
| SCHEMBL22423316 | 0.76 | NT5E (0.37) | ALDH1A1LMNATSHRKMT2ACYP2D6 | |
| SCHEMBL1034819 | 0.76 | NT5E (0.37) | ALDH1A1LMNATSHRKMT2ACYP2D6 | |
| SCHEMBL12302601 | 0.76 | NT5E (0.45) | ALDH1A1LMNATSHRKMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853175-B2 | Phenethylsulfone isoindoline derivatives and their use | CELGENE CORPORATION (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120178708-A1 | PHENETHYLSULFONE ISOINDOLINE DERIVATIVES AND THEIR USE | CELGENE CORPORATION (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178708-A1 | PHENETHYLSULFONE ISOINDOLINE DERIVATIVES AND THEIR USE | CYP3A43, UGT2B7, CYP2D6 | ALDH1A1 2224/4885ELANE 506/4885LMNA 2685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.