Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 2/20 | 0.42 |
| ▸ | GALR1 | P47211 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031098 | 1.00 | GALR2 (0.42) | GALR2GALR1EGFRBTKDRD1 | |
| SCHEMBL1332139 | 0.89 | GABRA1 (0.43) | USP2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL1332135 | 0.89 | GABRA1 (0.43) | USP2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL1334057 | 0.85 | GALR2 (0.42) | GALR2GALR1DRD1LMNAMAPK1 | |
| SCHEMBL1334058 | 0.85 | GALR2 (0.42) | GALR2GALR1DRD1LMNAMAPK1 | |
| SCHEMBL1332909 | 0.79 | GRM5 (0.39) | DRD1USP2ALDH1A1LMNACYP1A2 | |
| SCHEMBL1332911 | 0.79 | GRM5 (0.39) | DRD1USP2ALDH1A1LMNACYP1A2 | |
| SCHEMBL6885645 | 0.77 | GRM5 (0.48) | MAPK1CCNT1IRAK4MAPT | |
| SCHEMBL1334209 | 0.74 | GRM5 (0.41) | ALDH1A1MAPK1IRAK4ABL1MAPT | |
| SCHEMBL1334210 | 0.74 | GRM5 (0.41) | ALDH1A1MAPK1IRAK4ABL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513242-B2 | Pyrimidine compounds and methods of making and using same | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CYSTIC FIBROSIS FOUNDATION | 2011-11-17 | — | — | US | disclosed |
| WO-2011008931-A2 | ARYLPYRIMIDINE COMPOUNDS AND COMBINATION THERAPY COMPRISING SAME FOR TREATING CYSTIC FIBROSIS & RELATED DISORDERS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CFTR, GPR17, TYMS | GALR2 4500/4885GALR1 4245/4885EGFR 2118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.