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GABRA1

Gamma-aminobutyric acid receptor subunit alpha-1 · P14867 · GABRA1 on Sugi Atlas →

273,278 patent compounds predicted against GABRA1, 130,655 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL33214 SCHEMBL33214 0.52 19/20
SCHEMBL26584 SCHEMBL26584 0.51 19/20
Iomazenil Iomazenil (SCHEMBL41658) 0.71 13/20
SCHEMBL9107 SCHEMBL9107 0.56 12/20
SCHEMBL8532 SCHEMBL8532 1.00 11/20
Flunitrazepam Flunitrazepam (SCHEMBL44169) 1.00 10/20
SCHEMBL9035 SCHEMBL9035 0.56 10/20
SCHEMBL8632 SCHEMBL8632 0.54 10/20
SCHEMBL8856 SCHEMBL8856 0.53 10/20
Ro-54864 Ro-54864 (SCHEMBL60200) 0.85 9/20
SCHEMBL8670 SCHEMBL8670 0.57 9/20
SCHEMBL9273 SCHEMBL9273 0.53 9/20
SCHEMBL8931 SCHEMBL8931 0.51 9/20
SCHEMBL8932 SCHEMBL8932 0.51 9/20

Clinical trials — most relevant to GABRA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Attenuate the Stress Response in Laparoscopic Cholecystectomy PHASE4NOT_YET_RECRUITING
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex PHASE4COMPLETED
Bispectral Index-guided Sedation for Flexible Bronchoscopy PHASE4COMPLETED
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence. PHASE4COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28 PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk nanCOMPLETED
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED
Effect of Gabapentin on GABA Concentration and Emotional Processing nanCOMPLETED
Effects of Flumazenil on Brain Excitability nanCOMPLETED
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain nanRECRUITING
Correlation Between Immune Metabolism in Patients With Benzodiazepine Poisoning and Patients'Mental Disorders nanUNKNOWN
Mechanisms of Human Plasticity in the Human System nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GABRA1 binder may also engage these)

ProteinNameSimilarity
Q4R534 — 1.000 Q4R534 →
P08219 — 1.000 P08219 →
P62813 — 1.000 P62813 →
Q5R6B2 — 1.000 Q5R6B2 →
P62812 — 1.000 P62812 →
P19150 — 0.999 P19150 →
Q8BHJ7 — 0.987 Q8BHJ7 →
P19969 — 0.987 P19969 →
GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 0.985 landscape →
Q08E50 — 0.984 Q08E50 →
P26049 — 0.972 P26049 →
P10064 — 0.972 P10064 →
P23576 — 0.971 P23576 →
P20236 — 0.970 P20236 →
GABRA3 Gamma-aminobutyric acid receptor subunit alpha-3 0.970 landscape →
P10063 — 0.966 P10063 →
P26048 — 0.965 P26048 →
Q5RCC5 — 0.963 Q5RCC5 →
GABRA2 Gamma-aminobutyric acid receptor subunit alpha-2 0.961 landscape →
GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 0.960 landscape →
GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 0.960 landscape →
P50571 — 0.959 P50571 →
P18508 — 0.959 P18508 →
P15431 — 0.959 P15431 →
P63079 — 0.959 P63079 →
Q5REA1 — 0.956 Q5REA1 →
P08220 — 0.956 P08220 →
P63080 — 0.955 P63080 →
Q90845 — 0.953 Q90845 →
GABRG2 Gamma-aminobutyric acid receptor subunit gamm 0.952 landscape →