Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 3/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10313803 | 0.86 | BRD4 (0.40) | BRD4KCNH2PI4KBMAPK14 | |
| SCHEMBL10276148 | 0.85 | BRD4 (0.41) | BRD4KCNH2CCNT1CDK9PI4KB | |
| SCHEMBL10276207 | 0.85 | BRD4 (0.43) | BRD4KCNH2CCNT1CDK9PI4KB | |
| SCHEMBL10276542 | 0.84 | BRD4 (0.41) | BRD4CCNT1CDK9PI4KBIDH1 | |
| SCHEMBL10282687 | 0.83 | BRD4 (0.43) | BRD4CCNT1CDK9PI4KBIDH1 | |
| SCHEMBL10275295 | 0.82 | MAPK14 (0.37) | KCNH2PI4KBGRIN1GRIN2BMAPK14 | |
| SCHEMBL10313872 | 0.81 | BRD4 (0.39) | BRD4KCNH2PI4KBMAPK14FNTA | |
| SCHEMBL10276206 | 0.78 | FNTA (0.36) | KCNH2MAPK14FNTAFNTBPGGT1B | |
| SCHEMBL10276292 | 0.78 | BRD4 (0.43) | BRD4KCNH2CCNT1CDK9PI4KB | |
| SCHEMBL10313834 | 0.76 | BRD4 (0.41) | BRD4KCNH2PI4KBMAPK14FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | BRD4 3228/4885KCNH2 1984/4885CCNT1 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.