Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 7/20 | 0.39 |
| ▸ | PARP1 | P09874 | 5/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300231 | 0.80 | GRM5 (0.44) | GRM5CYP1A2GABRG2GABRB3GABRA5 | |
| SCHEMBL10008159 | 0.77 | GRM5 (0.53) | GRM5CYP1A2GABRG2GABRB3GABRA5 | |
| SCHEMBL10007959 | 0.75 | GRM5 (0.63) | GRM5CYP1A2GABRG2GABRB3GABRA5 | |
| SCHEMBL19153633 | 0.74 | PARP10 (0.49) | GRM5CYP1A2GABRG2GABRB3GABRA5 | |
| SCHEMBL30130624 | 0.74 | PARP10 (0.49) | GRM5CYP1A2GABRG2GABRB3GABRA5 | |
| SCHEMBL10314900 | 0.73 | GRM5 (0.59) | GRM5CYP1A2GABRG2GABRB3GABRA5 | |
| SCHEMBL721801 | 0.73 | GRM5 (0.42) | GRM5CYP1A2GABRG2GABRB3GABRA5 | |
| SCHEMBL23649631 | 0.71 | GRM5 (0.46) | GRM5CYP1A2PARP10PARP11PARP1 | |
| SCHEMBL10008839 | 0.71 | ACHE (0.49) | GRM5CYP1A2PARP10PARP11PARP1 | |
| SCHEMBL3403552 | 0.71 | GRM5 (0.46) | GRM5CYP1A2PARP10PARP11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853237-B2 | Naphthyridinone analogs as mGluR5 positive allosteric modulators | VANDERBILT UNIVERSITY (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120172391-A1 | NAPHTHYRIDINONE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172391-A1 | NAPHTHYRIDINONE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | GRM5, GRIK5, GRM1 | GRM5 1/4885CYP1A2 3633/4885GABRG2 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.