SCHEMBL10315430

SCHEMBL10315430

Cc1cc(C)cc(-c2cc3nc(-c4ccc(N(c5ccccc5)c5ccc(-c6nc7ccccc7o6)cc5)cc4)c(-c4ccc(N(c5ccccc5)c5ccc(-c6nc7ccccc7o6)cc5)cc4)nc3cc2-c2cc(C)cc(C)c2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 11/20 0.46
RAB9A P51151 9/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
ATM Q13315 1/20 0.46
SMN1; SMN2 Q16637 8/20 0.44
KDM4E B2RXH2 8/20 0.44
HPGD P15428 7/20 0.44
CASP3 P42574 3/20 0.44
SENP8 Q96LD8 2/20 0.44
SENP7 Q9BQF6 2/20 0.44
SENP6 Q9GZR1 2/20 0.44
POLB P06746 1/20 0.44
MAPT P10636 6/20 0.42
TP53 P04637 4/20 0.42
ALDH1A1 P00352 7/20 0.42
USP2 O75604 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
HCRTR1 O43613 2/20 0.41
NFKB1 P19838 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10315204 0.99 NPC1 (0.46) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10315434 0.92 NPC1 (0.48) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10315207 0.92 NPC1 (0.49) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10315196 0.91 NPC1 (0.50) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10315421 0.90 NPC1 (0.45) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10315179 0.90 NPC1 (0.48) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10315424 0.90 NPC1 (0.48) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10125938 0.90 NPC1 (0.52) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10126061 0.90 NPC1 (0.54) NPC1RAB9AMEN1KMT2AATM
SCHEMBL10315198 0.89 NPC1 (0.45) NPC1RAB9AMEN1KMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8216696-B2 Quinoxaline derivative, and light emitting element, light emitting device and electronic appliance using the same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-07-10 US disclosed
US-8216696-B2 Quinoxaline derivative, and light emitting element, light emitting device and electronic appliance using the same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-07-10 US disclosed
EP-2067778-A1 Quinoxaline derivative, and light emitting element, licht emitting device and electronic appliance using the same SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2009-06-10 EP disclosed