Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11983772 | 1.00 | CA12 (0.50) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL11906012 | 0.93 | CA9 (0.46) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL6877904 | 0.93 | CA9 (0.46) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL10315741 | 0.92 | CA12 (0.50) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL11983774 | 0.92 | CA12 (0.50) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL18220762 | 0.91 | CA12 (0.44) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL29576896 | 0.88 | CA1 (0.48) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL18220760 | 0.88 | CA1 (0.47) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL30466798 | 0.88 | CA12 (0.53) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL19649037 | 0.85 | CA12 (0.56) | CA12CA1CA9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-8217076-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-07-10 | — | — | US | disclosed |
| US-20100029731-A1 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029731-A1 | Method for preparing largazole analogs and uses thereof | CYP51A1, ADPRS, LPXN | CA12 1903/4885CA1 2511/4885CA9 1234/4885 |
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | CYP51A1, ADPRS, LPXN | CA12 1903/4885CA1 2511/4885CA9 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.