Sugi Predict

Sugi Predict / Targets / ADPRS

ADPRS

ADP-ribosylhydrolase ARH3 · Q9NX46 · ADPRS on Sugi Atlas →

116 patent compounds predicted against ADPRS, 107 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL17845344 SCHEMBL17845344 1.00 1/20
SCHEMBL17845324 SCHEMBL17845324 0.82 1/20
SCHEMBL17845673 SCHEMBL17845673 0.80 1/20
SCHEMBL17845329 SCHEMBL17845329 0.79 1/20
SCHEMBL20360119 SCHEMBL20360119 0.79 1/20
SCHEMBL17845613 SCHEMBL17845613 0.78 1/20
SCHEMBL17845640 SCHEMBL17845640 0.78 1/20
SCHEMBL31315581 SCHEMBL31315581 0.78 1/20
SCHEMBL20365040 SCHEMBL20365040 0.77 1/20
SCHEMBL17845368 SCHEMBL17845368 0.77 1/20
SCHEMBL17845627 SCHEMBL17845627 0.76 1/20
SCHEMBL17845342 SCHEMBL17845342 0.76 1/20
SCHEMBL17845522 SCHEMBL17845522 0.75 1/20
SCHEMBL20359234 SCHEMBL20359234 0.75 1/20
SCHEMBL17845478 SCHEMBL17845478 0.74 1/20
SCHEMBL17845440 SCHEMBL17845440 0.74 1/20
SCHEMBL31121997 SCHEMBL31121997 0.74 1/20
SCHEMBL17845396 SCHEMBL17845396 0.73 1/20
SCHEMBL17845456 SCHEMBL17845456 0.73 1/20
SCHEMBL17845357 SCHEMBL17845357 0.73 1/20

Clinical trials — most relevant to ADPRS by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies PHASE1/PHASE2RECRUITING
A Phase I Trial of SHR3162 in Subjects With Advanced Solid Tumors PHASE1COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
Role of Genetic Factors in the Development of Lung Disease nanRECRUITING
Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2) nanCOMPLETED
The Cognitive Resilience Study nanCOMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH) nanWITHDRAWN
GARM II: A Study on the Genetics of Age-related Maculopathy nanACTIVE_NOT_RECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome nanACTIVE_NOT_RECRUITING
Stress and Treatment Response in Puerto Rican Children With Asthma nanCOMPLETED
Towards an Easy-to-use Adrenal Cancer/Tumor Identity Card nanCOMPLETED
Characterizing a 5P-Linked BHR Susceptibility Locus nanCOMPLETED
Identification of an Asthma Susceptibility Gene on 3P nanCOMPLETED
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study) nanRECRUITING
Telomeres Length in Israeli Fibrotic ILD Patients nanENROLLING_BY_INVITATION
Gene Analysis of Parkinson's Disease nanCOMPLETED
Genetics of Neonatal Encephalopathy and Related Disorders nanRECRUITING
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve nanUNKNOWN
Study of Constitutional Platelet Disease nanUNKNOWN
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) nanCOMPLETED
Study of a Candidate Gene Involved in Goldenhar Syndrome. nanCOMPLETED
Biomarkers in Patients With Rhabdomyosarcoma nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a ADPRS binder may also engage these)

ProteinNameSimilarity
Q8CG72 — 1.000 Q8CG72 →
Q5ZI51 — 0.999 Q5ZI51 →
Q3SYV9 — 0.999 Q3SYV9 →
H3BCW1 — 0.988 H3BCW1 →
Q28FQ6 — 0.982 Q28FQ6 →
Q66HT8 — 0.979 Q66HT8 →
Q02589 — 0.977 Q02589 →
P54922 — 0.975 P54922 →
P54923 — 0.972 P54923 →
Q32KR8 — 0.969 Q32KR8 →
Q865R1 — 0.959 Q865R1 →
Q8IW45 — 0.959 Q8IW45 →
Q9CZ42 — 0.958 Q9CZ42 →
O75191 — 0.958 O75191 →
Q58H57 — 0.957 Q58H57 →
D4AAT7 — 0.957 D4AAT7 →
Q9NVH0 — 0.956 Q9NVH0 →
E2QUI9 — 0.956 E2QUI9 →
Q9N0V7 — 0.956 Q9N0V7 →
Q8R123 — 0.956 Q8R123 →
Q7Z3D6 — 0.955 Q7Z3D6 →
P97364 — 0.955 P97364 →
Q9FJN7 — 0.955 Q9FJN7 →
Q3TNA1 — 0.955 Q3TNA1 →
Q7ZW24 — 0.955 Q7ZW24 →
P47823 — 0.955 P47823 →
A2AV36 — 0.955 A2AV36 →
Q99611 — 0.955 Q99611 →
Q8MIR4 — 0.955 Q8MIR4 →
COASY Bifunctional coenzyme A synthase 0.955 landscape →