Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10316529 | 0.83 | BACE1 (0.39) | BACE1KDM1AOPRM1PDE4BOPRD1 | |
| SCHEMBL10316542 | 0.83 | BACE1 (0.39) | BACE1KDM1AOPRM1PDE4BOPRD1 | |
| SCHEMBL1441138 | 0.81 | BACE1 (0.54) | BACE1BACE2CTSD | |
| SCHEMBL1441476 | 0.79 | BACE1 (0.47) | BACE1BACE2 | |
| SCHEMBL1441018 | 0.75 | BACE1 (0.63) | BACE1BACE2CTSD | |
| SCHEMBL1441073 | 0.75 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL1441155 | 0.75 | BACE1 (0.50) | BACE1BACE2 | |
| SCHEMBL1440516 | 0.75 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL13268484 | 0.75 | BACE1 (0.34) | BACE1KDM1AOPRM1PDE4BOPRD1 | |
| SCHEMBL1441215 | 0.74 | BACE1 (0.49) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475658-A1 | 2 -AMINODIHYDRO [1, 3]THIAZINES AS BACE 2 INHIBITORS FOR THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2012-07-18 | — | — | EP | claimed |
| EP-2475658-A1 | 2 -AMINODIHYDRO [1, 3]THIAZINES AS BACE 2 INHIBITORS FOR THE TREATMENT OF DIABETES | F. Hoffmann-La Roche AG (CH) | 2012-07-18 | — | — | EP | disclosed |