Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13268463 | 0.82 | BACE1 (0.40) | BACE1KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL1978685 | 0.79 | BACE2 (0.44) | BACE1BACE2 | |
| SCHEMBL1979164 | 0.75 | BACE1 (0.59) | BACE1BACE2 | |
| SCHEMBL1978595 | 0.75 | BACE1 (0.60) | BACE1BACE2 | |
| SCHEMBL10316565 | 0.75 | BACE1 (0.37) | BACE1KDM1AOPRM1OPRD1OPRK1 | |
| SCHEMBL1978958 | 0.74 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL1978950 | 0.74 | BACE1 (0.61) | BACE1BACE2 | |
| SCHEMBL1978632 | 0.74 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL1980140 | 0.73 | BACE1 (0.61) | BACE1BACE2 | |
| SCHEMBL1979859 | 0.73 | BACE1 (0.61) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509966-A1 | AMINO OXAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | claimed |
| EP-2509966-A1 | AMINO OXAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | disclosed |