Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.87 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.87 |
| ▸ | AR | P10275 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.70 |
| ▸ | HTR6 | P50406 | 1/20 | 0.70 |
| ▸ | ESRRG | P62508 | 1/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL21681661 | 1.00 | ESR1 (0.87) | ESR1ESR2ALDH1A1CYP3A4AR | |
| Bicarbonate SCHEMBL23683863 | 1.00 | ESR1 (0.87) | ESR1ESR2ALDH1A1CYP3A4AR | |
| Bisphenol A SCHEMBL4809570 | 0.96 | ESR1 (0.79) | ESR1ESR2ALDH1A1CYP3A4AR | |
| SCHEMBL9353524 | 0.93 | ESR1 (1.00) | ESR1ESR2ALDH1A1CYP3A4AR | |
| Bisphenol A SCHEMBL1940373 | 0.93 | ESR1 (0.80) | ESR1ESR2ALDH1A1CYP3A4AR | |
| SCHEMBL51117 | 0.93 | ESR1 (1.00) | ESR1ESR2ALDH1A1CYP3A4AR | |
| Bisphenol A SCHEMBL23414108 | 0.93 | ESR1 (0.80) | ESR1ESR2ALDH1A1CYP3A4AR | |
| SCHEMBL4310025 | 0.93 | ESR1 (1.00) | ESR1ESR2ALDH1A1CYP3A4AR | |
| SCHEMBL28822358 | 0.92 | ESR1 (0.80) | ESR1ESR2ALDH1A1CYP3A4AR | |
| SCHEMBL10953906 | 0.92 | ESR1 (0.80) | ESR1ESR2ALDH1A1CYP3A4AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360221-B1 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2007-12-12 | — | — | EP | claimed |
| EP-1358246-B1 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2006-07-12 | — | — | EP | claimed |
| EP-1358247-B1 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2006-06-21 | — | — | EP | claimed |
| EP-1399498-B1 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2006-06-21 | — | — | EP | claimed |
| EP-1353971-B1 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2005-05-11 | — | — | EP | claimed |
| EP-1360221-A1 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2003-11-12 | — | — | EP | claimed |
| EP-1358246-A2 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2003-11-05 | — | — | EP | claimed |
| EP-1358247-A2 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002055585-A2 | MELT POLYCARBONATE CATALYST SYSTEMS | GEN ELECTRIC (US) | 2002-07-18 | — | — | WO | claimed |
| WO-2002055583-A2 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2002-07-18 | — | — | WO | claimed |
| WO-2002055584-A1 | MELT POLYCARBONATE CATALYST SYSTEMS | GENERAL ELECTRIC COMPANY (US) | 2002-07-18 | — | — | WO | claimed |
| US-6395862-B1 | CONTACTING DIARYLOXY COMPOUND WITH DIHYDRIC PHENOL IN THE PRESENCE OF ALKALI METAL TRIAZINE PYRIDYL SULFONATE, CARBOXY OR PHOSPHONATE | GENERAL ELECTRIC COMPANY | 2002-05-28 | — | — | US | claimed |
| US-6376640-B1 | USING CESIUM POLYMERIZATION CATALYST | GENERAL ELECTRIC COMPANY | 2002-04-23 | — | — | US | claimed |
| US-6323304-B1 | CONTACTING A DIARYLOXY COMPOUND WITH A DIHYDRIC PHENOL COMPOUND IN THE PRESENCE OF CATALYST COMPRISED OF ALKALI OR ALKALINE EARTH METAL-TRANSITION METAL FLUORIDE COMPOUND AND IN PRESENCE OF COCATALYST | GENERAL ELECTRIC COMPANY | 2001-11-27 | — | — | US | claimed |
| US-6323303-B1 | POLYMERIZING DIARYLOXY COMPOUND WITH A DIHYDRIC PHENOL COMPOUND IN THE PRESENCE OF A RUTHENIUM (II) OR RUTHENIUM (III) COMPOUND OR COMPLEX; OPTIONALLY IN PRESENCE OF A TETRAALKYL AMMONIUM OR TETRAALKYL PHOSPHONIUM SALT | GENERAL ELECTRIC COMPANY | 2001-11-27 | — | — | US | claimed |
| US-6303737-B1 | POLYCONDENSATION CATALYSTS WHICH ARE SALTS OF CERTAIN PHENANTHROLINE COMPOUNDS; EXCELLENT POLYMERIZATION RATES; REDUCING THE LEVEL OF BRANCHING SIDE REACTION, I.E., FORMATION OF FRIES PRODUCT | GENERAL ELECTRIC COMPANY | 2001-10-16 | — | — | US | claimed |
| US-6291631-B1 | CONTACTING DIARYLOXY COMPOUND WITH A DIHYDRIC PHENOL COMPOUND IN THE POLYMERIZATION CATALYST UNDER POLYCARBONATE MELT POLYMERIZATION CONDITIONS | GENERAL ELECTRIC COMPANY | 2001-09-18 | — | — | US | claimed |
| EP-2561004-A1 | POLYCARBONATE COPOLYMER | Styron Europe GmbH (CH) | 2013-02-27 | — | — | EP | disclosed |
| US-6184334-B1 | HEATING, IN ONE OR MORE STAGES, MIXTURE COMPRISING DIPHENOL AND DIARYLCARBONATE; INTRODUCING IN SAME STAGE OR DIFFERENT STAGES ALKALI METAL SALTS OF OXOACIDS OF SULFUR AS POLYMERIZATION CATALYST | GENERAL ELECTRIC COMPANY | 2001-02-06 | — | — | US | disclosed |
| US-6184335-B1 | HEATING, IN ONE OR MORE STAGES, MIXTURE COMPRISING DIPHENOL AND DIARYLCARBONATE; IN THE SAME STAGE OR DIFFERENT STAGES INTRODUCING CATALYTICALLY EFFECTIVE AMOUNT OF AN ALKALI AND/OR ALKALI EARTH METAL SALT OF ARYL SULFONIC ACID | GENERAL ELECTRIC COMPANY | 2001-02-06 | — | — | US | disclosed |