Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 6/20 | 0.33 |
| ▸ | BRD1 | O95696 | 2/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3300783 | 0.96 | F2 (0.38) | F2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10317266 | 0.88 | F2 (0.38) | F2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10318655 | 0.87 | F2 (0.36) | F2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3298096 | 0.86 | F2 (0.39) | F2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3298929 | 0.82 | F2 (0.35) | F2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4553849 | 0.81 | F2 (0.32) | F2 | |
| SCHEMBL13390112 | 0.80 | DGAT1 (0.32) | F2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13409455 | 0.80 | F2 (0.30) | F2 | |
| SCHEMBL3295640 | 0.79 | DGAT1 (0.30) | F2 | |
| SCHEMBL3301345 | 0.77 | STS (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |