Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 18/20 | 0.69 |
| ▸ | MET | P08581 | 7/20 | 0.69 |
| ▸ | EGFR | P00533 | 5/20 | 0.69 |
| ▸ | SRC | P12931 | 5/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.54 |
| ▸ | ERN1 | O75460 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.54 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.54 |
| ▸ | CSK | P41240 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10318460 | 0.97 | AXL (0.66) | AXLMETEGFRSRCPLK4 | |
| SCHEMBL10317731 | 0.92 | AXL (0.68) | AXLMETEGFRSRCPLK4 | |
| SCHEMBL10317231 | 0.91 | AXL (0.79) | AXLMETEGFRSRC | |
| SCHEMBL10317020 | 0.88 | AXL (0.62) | AXLMETEGFRSRC | |
| SCHEMBL1591274 | 0.88 | AXL (0.88) | AXLMETEGFRSRCPLK4 | |
| SCHEMBL10317123 | 0.88 | AXL (0.62) | AXLMETEGFRSRC | |
| SCHEMBL10318848 | 0.85 | AXL (0.60) | AXLMETEGFRSRC | |
| SCHEMBL1591716 | 0.85 | AXL (0.84) | AXLMETEGFRSRCPLK4 | |
| SCHEMBL10321487 | 0.83 | AXL (0.79) | AXLMETEGFRSRC | |
| SCHEMBL10318710 | 0.82 | AXL (0.50) | AXLMETEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | claimed |