Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 20/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | MET | P08581 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10319147 | 0.93 | AXL (0.59) | AXLEGFRMETSRC | |
| SCHEMBL10319931 | 0.92 | AXL (0.61) | AXLEGFRMETSRC | |
| SCHEMBL10317123 | 0.91 | AXL (0.62) | AXLEGFRMETSRC | |
| SCHEMBL10318130 | 0.89 | AXL (0.75) | AXLEGFRMETSRC | |
| SCHEMBL10317984 | 0.89 | AXL (0.56) | AXLEGFRMETSRC | |
| SCHEMBL1591652 | 0.86 | AXL (0.79) | AXLEGFRMETSRC | |
| SCHEMBL10318460 | 0.86 | AXL (0.66) | AXLEGFRMETSRC | |
| SCHEMBL10316992 | 0.85 | AXL (0.69) | AXLEGFRMETSRC | |
| SCHEMBL10317543 | 0.85 | AXL (0.75) | AXLEGFRMETSRC | |
| SCHEMBL10317731 | 0.85 | AXL (0.68) | AXLEGFRMETSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | claimed |