Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.31 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
| ▸ | LATS1 | O95835 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13390372 | 0.95 | IRAK4 (0.34) | IRAK4SUV39H2STK17BSTK17ACKS1B | |
| SCHEMBL3300747 | 0.90 | MAPT (0.33) | IRAK4KEAP1NFE2L2F2TP53 | |
| SCHEMBL13390518 | 0.88 | CCR9 (0.34) | IRAK4TP53MAPTHSD17B10DGAT1 | |
| SCHEMBL3301519 | 0.88 | KEAP1 (0.33) | IRAK4KEAP1NFE2L2F2ALDH1A1 | |
| SCHEMBL3295593 | 0.87 | IRAK4 (0.34) | IRAK4SUV39H2STK17BSTK17ACKS1B | |
| SCHEMBL3298992 | 0.87 | KDM4D (0.34) | IRAK4KEAP1NFE2L2F2 | |
| SCHEMBL3295567 | 0.86 | TMEM97 (0.33) | IRAK4KEAP1NFE2L2F2MAPT | |
| SCHEMBL13391255 | 0.86 | PLAU (0.33) | IRAK4KEAP1NFE2L2F2ALDH1A1 | |
| SCHEMBL13390343 | 0.86 | IRAK4 (0.33) | IRAK4TP53MAPTHSD17B10DGAT1 | |
| Hydrochloric Acid SCHEMBL3300119 | 0.86 | KEAP1 (0.34) | IRAK4KEAP1NFE2L2F2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |