KEAP1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL92951	0.60	16/20
SCHEMBL81704	0.58	16/20
SCHEMBL21124	0.64	7/20
SCHEMBL39163	0.43	7/20
Phenylhexyl Isothiocyanate (SCHEMBL7809)	0.57	6/20
Hydrochloric Acid (SCHEMBL79280)	0.42	4/20
SCHEMBL102324	0.40	4/20
SCHEMBL59151	0.64	3/20
SCHEMBL1109	0.56	3/20
SCHEMBL56650	0.56	3/20
SCHEMBL28432	0.55	3/20
SCHEMBL92828	0.54	3/20
SCHEMBL69960	0.53	3/20
SCHEMBL86371	0.41	3/20
SCHEMBL33492	0.38	3/20
Topotecan (SCHEMBL3836)	1.00	2/20
Topotecan (SCHEMBL7247)	1.00	2/20
Topotecan (SCHEMBL7248)	1.00	2/20
SCHEMBL9029	1.00	2/20
Topotecan (SCHEMBL10278)	1.00	2/20

Clinical trials — most relevant to KEAP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients	PHASE4	UNKNOWN
Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Proteinuric Chronic Kidney Disease	PHASE3	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy	PHASE2	RECRUITING
Clinical Trial With Broccoli Sprout Extract to Patients With Type 2 Diabetes	PHASE2	COMPLETED
Effect of Oral Supplementation With Curcumin in Patients With Proteinuric Diabetic Kidney Disease	PHASE2	UNKNOWN
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD	PHASE2	COMPLETED
A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's Ataxia	PHASE2	COMPLETED
Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS	PHASE1/PHASE2	COMPLETED
Glucosamine Sulphate Versus Ginger in Non-Surgical Periodontal Therapy	PHASE2	COMPLETED
Electrophilic Fatty Acid Derivatives in Asthma	PHASE1	COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Feasibility Test of Folic Acid on Acute Kidney Injury	EARLY_PHASE1	NOT_YET_RECRUITING
ADAPT: Efficacy of a Dietary Supplement During and After Exercise	nan	COMPLETED
Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC)	nan	UNKNOWN
Tecfidera Diffusion Tensor Imaging	nan	COMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects	nan	COMPLETED
Treatment of Metastatic Cancer in Terminally Diagnosed Patients	nan	AVAILABLE
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.	nan	ACTIVE_NOT_RECRUITING
Effects of Lead Exposure on Ferroptosis Pathway	nan	UNKNOWN
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING
Effect of Total Knee Arthroplasty on Sarcopenia in Patients With Osteoarthritis in the Knee	nan	COMPLETED
Muscle Wasting in Cancer (MWIC)	nan	COMPLETED
Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders	nan	RECRUITING
Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials	nan	RECRUITING
Effect of Protein on Endoplasmic Reticulum Stress	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a KEAP1 binder may also engage these)

Protein	Name	Similarity
Q5R774	—	1.000	Q5R774 →
Q9Z2X8	—	1.000	Q9Z2X8 →
Q684M4	—	1.000	Q684M4 →
P57790	—	1.000	P57790 →
A0A2R8Q1W5	—	0.990	A0A2R8Q1W5 →
E1B932	—	0.975	E1B932 →
Q9C0H6	—	0.974	Q9C0H6 →
E7F6F9	—	0.974	E7F6F9 →
Q6NRH0	—	0.974	Q6NRH0 →
Q2T9Z7	—	0.970	Q2T9Z7 →
Q6TDP3	—	0.970	Q6TDP3 →
Q5U374	—	0.970	Q5U374 →
Q9P2J3	—	0.970	Q9P2J3 →
Q6TDP4	—	0.969	Q6TDP4 →
Q8R2H4	—	0.969	Q8R2H4 →
Q5REP9	—	0.967	Q5REP9 →
Q53G59	—	0.967	Q53G59 →
Q8K430	—	0.966	Q8K430 →
Q6ZPT1	—	0.964	Q6ZPT1 →
Q5ZLD3	—	0.963	Q5ZLD3 →
E9Q4F2	—	0.963	E9Q4F2 →
F1LZ52	—	0.963	F1LZ52 →
O94889	—	0.962	O94889 →
Q9NR64	—	0.961	Q9NR64 →
Q9P2N7	—	0.961	Q9P2N7 →
Q8BZM0	—	0.960	Q8BZM0 →
E0CZ16	—	0.960	E0CZ16 →
F1MBP6	—	0.960	F1MBP6 →
Q96PQ7	—	0.959	Q96PQ7 →
Q80TF4	—	0.959	Q80TF4 →