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SCHEMBL10317543

SCHEMBL10317543

COc1ccc2c(Oc3ccc(NS(=O)(=O)c4ccccc4OC(F)(F)F)c(F)c3)ccnc2c1OC

nearest known ligand 0.75

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 14/20 0.75
▸ SLC40A1 Q9NP59 1/20 0.47
▸ MRGPRX1 Q96LB2 2/20 0.47
▸ EGFR P00533 1/20 0.45
▸ MET P08581 1/20 0.45
▸ SRC P12931 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ SCN9A Q15858 1/20 0.42
▸ BRD4 O60885 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10318681 0.93 AXL (0.64) AXLSLC40A1MRGPRX1ALDH1A1MAPT
SCHEMBL10316949 0.92 AXL (0.63) AXLSLC40A1MRGPRX1EGFRMET
SCHEMBL10317039 0.90 AXL (0.63) AXLMRGPRX1ALDH1A1MAPTSCN9A
SCHEMBL10316977 0.89 AXL (0.75) AXL
SCHEMBL10318293 0.88 AXL (0.73) AXLMRGPRX1ALDH1A1MAPT
SCHEMBL10317984 0.87 AXL (0.56) AXLSLC40A1MRGPRX1EGFRMET
SCHEMBL10319281 0.87 AXL (0.73) AXL
SCHEMBL1592063 0.86 AXL (1.00) AXLEGFRMETSRC
SCHEMBL10319493 0.86 AXL (0.60) AXLSLC40A1MRGPRX1ALDH1A1MAPT
SCHEMBL10317131 0.85 AXL (0.73) AXLSCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2262772-B1 QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS MAX PLANCK GESELLSCHAFT (DE) 2012-07-18 — — EP claimed