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SCHEMBL10318293

SCHEMBL10318293

COc1ccc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C)c(F)c3)ccnc2c1OC

nearest known ligand 0.73

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 14/20 0.73
▸ MRGPRX1 Q96LB2 1/20 0.47
▸ POLB P06746 1/20 0.45
▸ GAA P10253 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ TRIM24 O15164 1/20 0.43
▸ BRD1 O95696 1/20 0.43
▸ BRPF1 P55201 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10318681 0.93 AXL (0.64) AXLMRGPRX1ALDH1A1MAPT
SCHEMBL10317039 0.93 AXL (0.63) AXLMRGPRX1POLBGAASMN1; SMN2
SCHEMBL10319493 0.90 AXL (0.60) AXLMRGPRX1POLBGAASMN1; SMN2
SCHEMBL10317118 0.90 AXL (0.59) AXLMRGPRX1POLBGAASMN1; SMN2
SCHEMBL10316977 0.89 AXL (0.75) AXL
SCHEMBL10319409 0.88 AXL (0.72) AXLMRGPRX1
SCHEMBL10317543 0.88 AXL (0.75) AXLMRGPRX1ALDH1A1MAPT
SCHEMBL10317695 0.87 AXL (0.58) AXLMRGPRX1POLBALDH1A1MAPT
SCHEMBL10319281 0.87 AXL (0.73) AXLPOLB
SCHEMBL10317131 0.87 AXL (0.73) AXLPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2262772-B1 QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS MAX PLANCK GESELLSCHAFT (DE) 2012-07-18 — — EP claimed