Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 20/20 | 0.76 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | MET | P08581 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10318287 | 0.94 | AXL (0.77) | AXLEGFRMETSRC | |
| SCHEMBL10318130 | 0.93 | AXL (0.75) | AXLEGFRMETSRC | |
| SCHEMBL10319147 | 0.89 | AXL (0.59) | AXLEGFRMETSRC | |
| SCHEMBL1592148 | 0.86 | AXL (1.00) | AXLEGFRMETSRC | |
| SCHEMBL10319698 | 0.84 | AXL (0.76) | AXLEGFRMETSRC | |
| SCHEMBL10318371 | 0.83 | AXL (0.64) | AXL | |
| SCHEMBL10316977 | 0.83 | AXL (0.75) | AXL | |
| SCHEMBL10319931 | 0.82 | AXL (0.61) | AXLEGFRMETSRC | |
| SCHEMBL1592205 | 0.82 | AXL (1.00) | AXLEGFRMETSRC | |
| SCHEMBL10317382 | 0.82 | AXL (0.60) | AXLEGFRMETSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | claimed |