Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032697 | 0.95 | TSHR (0.54) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL1030647 | 0.87 | HTT (0.59) | HTTSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL1031140 | 0.81 | NPSR1 (0.49) | SMN1; SMN2ALDH1A1TSHRPOLBKMT2A | |
| SCHEMBL1032186 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL1031916 | 0.80 | NPSR1 (0.51) | HTTTSHRLMNAMAPK1 | |
| SCHEMBL1032118 | 0.80 | POLB (0.40) | HTTSMN1; SMN2ALDH1A1LMNAMAPK1 | |
| SCHEMBL1033446 | 0.77 | NPC1 (0.53) | SMN1; SMN2ALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL1032474 | 0.77 | NPC1 (0.44) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL1030364 | 0.76 | MCHR1 (0.47) | SMN1; SMN2ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL763452 | 0.75 | HTT (0.78) | HTTSMN1; SMN2ALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |