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SCHEMBL10319409

SCHEMBL10319409

COc1ccc2c(Oc3ccc(NS(=O)(=O)c4ccccc4)c(F)c3)ccnc2c1OC

nearest known ligand 0.72

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 11/20 0.72
▸ SLC40A1 Q9NP59 5/20 0.55
▸ MEN1 O00255 1/20 0.48
▸ AGTR1 P30556 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ KIT P10721 1/20 0.44
▸ CKS1B P61024 1/20 0.43
▸ SKP2 Q13309 1/20 0.43
▸ MRGPRX1 Q96LB2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10318149 0.95 AXL (0.66) AXLSLC40A1MEN1AGTR1KMT2A
SCHEMBL10319009 0.94 AXL (0.64) AXLSLC40A1MEN1AGTR1KMT2A
SCHEMBL10317905 0.92 AXL (0.73) AXLSLC40A1MEN1AGTR1KMT2A
SCHEMBL10317649 0.92 AXL (0.63) AXLSLC40A1MEN1AGTR1KMT2A
SCHEMBL10316964 0.91 AXL (0.62) AXLSLC40A1MEN1AGTR1KMT2A
SCHEMBL10317890 0.91 AXL (0.61) AXLSLC40A1MEN1AGTR1KMT2A
SCHEMBL10317632 0.91 AXL (0.59) AXLSLC40A1MEN1AGTR1KMT2A
SCHEMBL10317039 0.90 AXL (0.63) AXLMEN1AGTR1KMT2AKIT
SCHEMBL10317016 0.90 AXL (0.58) AXLMEN1AGTR1KMT2AKIT
SCHEMBL10317750 0.90 AXL (0.58) AXLSLC40A1MEN1AGTR1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2262772-B1 QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS MAX PLANCK GESELLSCHAFT (DE) 2012-07-18 — — EP claimed