Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 11/20 | 0.64 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10318149 | 0.95 | AXL (0.66) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10317649 | 0.95 | AXL (0.63) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10319409 | 0.94 | AXL (0.72) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10317905 | 0.91 | AXL (0.73) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10316964 | 0.91 | AXL (0.62) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10318469 | 0.91 | SLC40A1 (0.52) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10317632 | 0.89 | AXL (0.59) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10317111 | 0.89 | PGR (0.59) | AXLSLC40A1MEN1KMT2APGR | |
| SCHEMBL10316968 | 0.88 | AXL (0.75) | AXLSLC40A1MEN1AGTR1KMT2A | |
| SCHEMBL10317016 | 0.88 | AXL (0.58) | AXLMEN1AGTR1KMT2ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | claimed |