Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10321971 | 1.00 | LMNA (0.44) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL1288426 | 1.00 | LMNA (0.44) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL31294147 | 0.98 | EPHX1 (0.46) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL16439941 | 0.98 | LMNA (0.43) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL14605829 | 0.98 | EPHX1 (0.46) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL4988968 | 0.98 | EPHX1 (0.46) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL16440016 | 0.96 | EPHX1 (0.45) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL16439945 | 0.96 | EPHX1 (0.45) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31294335 | 0.96 | EPHX1 (0.45) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 | |
| SCHEMBL16439906 | 0.96 | EPHX1 (0.45) | LMNAEPHX1SMN1; SMN2EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115947728-A | Dihydro pteridinone derivative containing sulfonyl and application thereof | 沈阳药科大学 | 2023-04-11 | — | — | CN | disclosed |
| EP-2481739-B1 | DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO LTD (CN) | 2016-12-14 | — | — | EP | disclosed |
| EP-2481739-A1 | DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2012-08-01 | — | — | EP | disclosed |
| US-20120184543-A1 | DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184543-A1 | DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | PLK2, PLK3, DMPK | LMNA 826/4885EPHX1 2962/4885SMN1; SMN2 4526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.