⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421623 | 0.73 | CRBN (0.32) | — | |
| SCHEMBL33371399 | 0.70 | CRBN (0.33) | — | |
| SCHEMBL1816977 | 0.70 | — | — | |
| SCHEMBL68773 | 0.70 | CRBN (0.33) | — | |
| SCHEMBL18551254 | 0.69 | — | — | |
| SCHEMBL11615125 | 0.69 | SLC6A2 (0.30) | — | |
| SCHEMBL7339316 | 0.69 | ALDH1A1 (0.31) | — | |
| SCHEMBL30300391 | 0.69 | — | — | |
| SCHEMBL3313254 | 0.69 | — | — | |
| SCHEMBL182774 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957119-A | Tetrahydroquinaxospiro 1, 3-indandione derivative and preparation method and application thereof | 武汉大学中南医院 | 2022-08-30 | — | — | CN | claimed |
| US-4171441-A | Preparation of quinazolin-2(1H)-ones | SANDOZ, INC. (US) | 1979-10-16 | — | — | US | claimed |
| EP-4739393-A1 | TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS | Merck Sharp & Dohme LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| EP-4017854-B1 | PYRAZINO[1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF | CIIMAR CENTRO INTERDISCIPLINAR DE INVESTIG MARINHA E AMBIENTAL (PT) | 2025-08-13 | — | — | EP | disclosed |
| WO-2025014788-A1 | TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS | MERCK SHARP & DOHME LLC (US) | 2025-01-16 | — | — | WO | disclosed |
| CN-114040911-B | As NAV1.8 2, 3-Dihydro-quinazoline Compounds as inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-10-22 | — | — | CN | disclosed |
| EP-4419094-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERPROLIFERATIVE, INFLAMMATORY, AND IMMUNOLOGICAL DISEASES, AND INFECTIONS | Edison Oncology (US) | 2024-08-28 | — | — | EP | disclosed |
| US-20240156808-A1 | Compositions and methods to improve the therapeutic benefit of suboptimally chemical compounds and biological therapies including substituted camptothecins such as irinotecan and topotecan for the treatment of benign and neoplastic hyperproliferative disease conditions, infections, inflammatory and immunological diseases | EDISON ONCOLOGY (US) | 2024-05-16 | — | — | US | disclosed |
| EP-4297746-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED COMPOUNDS AND THERAPIES FOR THE TREATMENT OF DISEASES | Edison Oncology (US) | 2024-01-03 | — | — | EP | disclosed |
| WO-2023069727-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERPROLIFERATIVE, INFLAMMATORY, AND IMMUNOLOGICAL DISEASES, AND INFECTIONS | EDISON ONCOLOGY (US) | 2023-04-27 | — | — | WO | disclosed |
| US-11446274-B2 | Use of dianhydrogalactitol or derivatives or analogs thereof for treatment of pediatric central nervous system malignancies | DEL MAR PHARMACEUTICALS (BC) LTD. (CA) | 2022-09-20 | — | — | US | disclosed |
| US-5521182-A | ACETYLCHOLINESTERASE INHIBITORS | EISAI CO., LTD. (JP) | 1996-05-28 | — | — | US | disclosed |
| US-5504088-A | ACETYLCHOLINE ESTERASE INHIBITORS; ALZHEIMER'S DISEASE AND OTHER DISEASES CAUSED BY A LOW CONCENTRATION OF CHOLINE | EISAI CO., LTD. (JP) | 1996-04-02 | — | — | US | disclosed |
| EP-0677516-A1 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-5292735-A | Cyclic amide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0468187-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1992-01-29 | — | — | EP | disclosed |
| US-4395550-A | Tetrahydro-2(1H)-quinazolinones and cyclohexene nitriles | SANDOZ LTD. (CH) | 1983-07-26 | — | — | US | disclosed |
| US-4066665-A | CHEMICAL INTERMEDIATES FOR QUINAZOLINONES | SANDOZ, INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-3996227-A | 7-Methyl-1-isopropyl-4-phenyl-5,6,7,8-tetrahydro-2(1H)-quinazolinone | SANDOZ, INC. (US) | 1976-12-07 | — | — | US | disclosed |
| US-3870720-A | POTASSIUM DERIVATIVES OF 2-PHENYL-6-SULPHAMYL-7-CHLORO-1,2,3,4-TETRAHYDRO-4-QUINAZOLINONE | CARISSIMI MASSIMO | 1975-03-11 | — | — | US | disclosed |