Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 13/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10323484 | 0.92 | DYRK1A (0.51) | DYRK1ADYRK1BMAPK8ROCK2ROCK1 | |
| SCHEMBL10323992 | 0.85 | DYRK1A (0.46) | DYRK1ADYRK1BCCNE1CDK2 | |
| SCHEMBL10323055 | 0.85 | DYRK1A (0.77) | DYRK1ADYRK1B | |
| SCHEMBL10323991 | 0.80 | DYRK1A (0.74) | DYRK1ADYRK1B | |
| SCHEMBL10323504 | 0.78 | DYRK1A (0.43) | DYRK1ADYRK1BMAPK8 | |
| SCHEMBL10323483 | 0.77 | DYRK1A (0.70) | DYRK1ADYRK1B | |
| SCHEMBL10447132 | 0.77 | DYRK1A (0.90) | DYRK1ADYRK1B | |
| Hydrochloric Acid SCHEMBL10323428 | 0.76 | DYRK1A (0.89) | DYRK1ADYRK1B | |
| SCHEMBL11952861 | 0.76 | DYRK1A (0.63) | DYRK1ADYRK1B | |
| SCHEMBL11952069 | 0.75 | DYRK1A (0.80) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | DYRK1A 654/4885DYRK1B 570/4885MAPK8 2282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.