Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 6/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353448 | 1.00 | MAPK8 (0.46) | MAPK8MAPK9MAPK10CSNK2A1MERTK | |
| SCHEMBL10323612 | 0.92 | MAPK8 (0.41) | MAPK8MAPK9MAPK10MERTKJAK2 | |
| SCHEMBL10353817 | 0.92 | MAPK8 (0.41) | MAPK8MAPK9MAPK10MERTKJAK2 | |
| SCHEMBL10353897 | 0.91 | CCNT1 (0.45) | MAPK8MAPK9MAPK10MERTKMAPK14 | |
| SCHEMBL10353785 | 0.91 | ACHE (0.43) | MAPK8MAPK9MAPK10MERTKJAK2 | |
| SCHEMBL10322915 | 0.91 | ACHE (0.43) | MAPK8MAPK9MAPK10MERTKJAK2 | |
| SCHEMBL10323457 | 0.91 | CCNT1 (0.45) | MAPK8MAPK9MAPK10MERTKMAPK14 | |
| SCHEMBL10353820 | 0.91 | ACHE (0.43) | MAPK8MAPK9MAPK10MERTKJAK2 | |
| SCHEMBL10322611 | 0.90 | MAPK9 (0.40) | MAPK8MAPK9MAPK10CSNK2A1MERTK | |
| SCHEMBL10354591 | 0.90 | MAPK9 (0.40) | MAPK8MAPK9MAPK10CSNK2A1MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362023-B2 | Pyrazolo pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 2013-01-29 | — | — | US | disclosed |
| WO-2012098068-A1 | PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | BIODURO (BEIJING) COMPANY LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | TYMS, TYMP, TP53 | MAPK8 1678/4885MAPK9 1108/4885MAPK10 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.