Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCAF1 | Q9Y4B6 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 11/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10323925 | 0.88 | DCAF1 (0.46) | DCAF1MAPK1 | |
| SCHEMBL10324846 | 0.83 | DYRK1A (0.51) | DCAF1MAPK1AURKA | |
| SCHEMBL10322147 | 0.83 | DYRK1A (0.51) | DCAF1MAPK1AURKA | |
| SCHEMBL10322647 | 0.77 | DYRK1A (0.48) | DCAF1MAPK1AURKA | |
| SCHEMBL22077638 | 0.76 | DCAF1 (0.43) | DCAF1MAPK1AURKACTSA | |
| SCHEMBL10322490 | 0.74 | ROCK2 (0.51) | DCAF1MAPK1AURKA | |
| SCHEMBL10324847 | 0.74 | DYRK1A (0.51) | MAPK1 | |
| SCHEMBL10322148 | 0.74 | DYRK1A (0.51) | MAPK1 | |
| SCHEMBL10323130 | 0.74 | ROCK2 (0.51) | DCAF1MAPK1AURKA | |
| SCHEMBL10324927 | 0.74 | ROCK2 (0.51) | DCAF1MAPK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | claimed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | DCAF1 1970/4885MAPK1 1900/4885AURKA 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.