Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 9/20 | 0.47 |
| ▸ | CDK2 | P24941 | 6/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353613 | 1.00 | MERTK (0.47) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10322858 | 0.92 | CCNT1 (0.47) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10353042 | 0.92 | CCNT1 (0.47) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10353580 | 0.89 | CDK2 (0.41) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10323069 | 0.89 | CCNT1 (0.44) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10353467 | 0.89 | CCNT1 (0.44) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10322577 | 0.89 | CDK2 (0.41) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10323278 | 0.87 | FLT3 (0.42) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10354223 | 0.87 | FLT3 (0.42) | MERTKCDK2CCNA2CCNE2CCNE1 | |
| SCHEMBL10353321 | 0.83 | CCNT1 (0.62) | CDK2CCNA2CCNT1CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362023-B2 | Pyrazolo pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 2013-01-29 | — | — | US | claimed |
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | BIODURO (BEIJING) COMPANY LTD. (CN) | 2012-07-19 | — | — | US | claimed |
| US-8362023-B2 | Pyrazolo pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 2013-01-29 | — | — | US | disclosed |
| WO-2012098068-A1 | PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | BIODURO (BEIJING) COMPANY LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | TYMS, TYMP, TP53 | MERTK 2006/4885CDK2 16/4885CCNA2 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.