Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | MERTK | Q12866 | 5/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10323069 | 1.00 | CCNT1 (0.44) | CCNT1MERTKAXLTYRO3NTRK1 | |
| SCHEMBL10353613 | 0.89 | MERTK (0.47) | CCNT1MERTKAXLTYRO3CCNE2 | |
| SCHEMBL10324055 | 0.89 | MERTK (0.47) | CCNT1MERTKAXLTYRO3CCNE2 | |
| SCHEMBL10322858 | 0.88 | CCNT1 (0.47) | CCNT1MERTKCCNE2CCNA2CCNE1 | |
| SCHEMBL10353042 | 0.88 | CCNT1 (0.47) | CCNT1MERTKCCNE2CCNA2CCNE1 | |
| SCHEMBL10354223 | 0.83 | FLT3 (0.42) | CCNT1MERTKAXLTYRO3CCNE2 | |
| SCHEMBL10353580 | 0.83 | CDK2 (0.41) | CCNT1MERTKAXLTYRO3CCNE2 | |
| SCHEMBL10323278 | 0.83 | FLT3 (0.42) | CCNT1MERTKAXLTYRO3CCNE2 | |
| SCHEMBL10322577 | 0.83 | CDK2 (0.41) | CCNT1MERTKAXLTYRO3CCNE2 | |
| SCHEMBL11892629 | 0.81 | ROCK2 (0.42) | NTRK1IGF1RPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362023-B2 | Pyrazolo pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | BIODURO (BEIJING) COMPANY LTD. (CN) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184508-A1 | PYRAZOLO PYRIMIDINES | TYMS, TYMP, TP53 | CCNT1 182/4885MERTK 2006/4885AXL 1246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.