Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13324138 | 0.92 | POLB (0.43) | DYRK1ACYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL13324069 | 0.77 | MAP4K4 (0.39) | DYRK1ARAB9AEGLN1ADORA3MAPT | |
| SCHEMBL13323859 | 0.75 | PIK3CD (0.48) | DYRK1AACHEAPPADORA3PIK3CA | |
| SCHEMBL15845695 | 0.71 | KMT2A (0.42) | DYRK1ACYP1A2CYP2C9CYP3A4PDCD1 | |
| SCHEMBL18057354 | 0.70 | CASP3 (0.38) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL4357991 | 0.69 | NPC1 (0.52) | DYRK1ACYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL15857827 | 0.69 | GAA (0.35) | CYP1A2CYP2C9CYP2C19CYP3A4NPC1 | |
| SCHEMBL4353200 | 0.68 | PIK3R1 (0.47) | DYRK1ACYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL3340735 | 0.68 | PDE5A (0.43) | APPMAPTHRH4HTT | |
| SCHEMBL4364664 | 0.68 | ADORA2A (0.42) | ACHEADORA3MAPTHRH4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270002-A1 | Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg (NL) | 2011-01-05 | — | — | EP | disclosed |
| WO-2010146173-A1 | QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-12-23 | — | — | WO | disclosed |