CASP3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL78538	0.53	20/20
SCHEMBL78539	0.53	20/20
SCHEMBL78540	0.53	20/20
SCHEMBL78288	0.57	16/20
SCHEMBL78289	0.57	16/20
SCHEMBL78290	0.57	16/20
SCHEMBL80166	0.51	14/20
SCHEMBL80167	0.51	14/20
SCHEMBL80168	0.51	14/20
SCHEMBL78880	0.51	11/20
SCHEMBL78881	0.51	11/20
SCHEMBL50008	1.00	7/20
SCHEMBL79203	1.00	6/20
SCHEMBL79983	0.62	6/20
Indigotindisulfonate (SCHEMBL40486)	0.44	6/20
SCHEMBL19918	0.76	5/20
Celastrol (SCHEMBL14954)	0.75	5/20
Benoxaprofen (SCHEMBL24413)	0.58	5/20
Benoxaprofen (SCHEMBL24414)	0.58	5/20
SCHEMBL61076	0.52	5/20

Clinical trials — most relevant to CASP3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation	PHASE4	ACTIVE_NOT_RECRUITING
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma	PHASE4	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation	PHASE2	COMPLETED
Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus	PHASE2	COMPLETED
Remote Ischemic Preconditioning of Human Myocardium	PHASE2	COMPLETED
18F-CP18 Imaging Studies for Cancer Treatment With Birinapant	PHASE2	WITHDRAWN
Metformin Treatment for Colon Cancer	PHASE2	COMPLETED
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Abraxane and Lapatinib in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer	EARLY_PHASE1	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Patient-Derived Organoids to Functionally Characterize Chemotherapy Resistance in Breast Cancer	nan	NOT_YET_RECRUITING
Serum Caspase 3, Annexin a2 and Soluble Fas Levels and Endometriosis	nan	COMPLETED
Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.	nan	UNKNOWN
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Apoptosis and Hepatitis B: The Role of Apoptosis in Patients Who Are HBeAg Negative	nan	UNKNOWN
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
Retrospective Evaluation of Melanocortin Receptor 4 Polymorphisms in Patients With GBM Treated With Radiochemotherapy	nan	COMPLETED
Cell Membrane Potential Regulates Spatial-Specific Mechanoptosis Resistance and Metastasis in Colorectal Cancer Via Mechanotransduction and the PVR/CD96 Axis	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CASP3 binder may also engage these)

Protein	Name	Similarity
Q5IS54	—	1.000	Q5IS54 →
P55213	—	1.000	P55213 →
P70677	—	1.000	P70677 →
Q5IS99	—	1.000	Q5IS99 →
Q2PFV2	—	1.000	Q2PFV2 →
Q95ND5	—	1.000	Q95ND5 →
Q8MJU1	—	0.999	Q8MJU1 →
Q08DY9	—	0.999	Q08DY9 →
Q8MKI5	—	0.998	Q8MKI5 →
Q60431	—	0.995	Q60431 →
Q8MJC3	—	0.989	Q8MJC3 →
F1NV61	—	0.983	F1NV61 →
P97864	—	0.979	P97864 →
CASP7	Caspase-7	0.979	landscape →
P55214	—	0.977	P55214 →
O08738	—	0.968	O08738 →
CASP6	Caspase-6	0.966	landscape →
O35397	—	0.963	O35397 →
A0A1D5PPP7	—	0.951	A0A1D5PPP7 →
Q3T0P5	—	0.951	Q3T0P5 →
P55866	—	0.938	P55866 →
O75601	—	0.923	O75601 →
P89116	—	0.922	P89116 →
Q9MZV7	—	0.922	Q9MZV7 →
Q5E9C1	—	0.920	Q5E9C1 →
Q9MZV6	—	0.919	Q9MZV6 →
CASP8	Caspase-8	0.918	landscape →
CASP1	Caspase-1	0.916	landscape →
P29452	—	0.916	P29452 →
Q9TV13	—	0.915	Q9TV13 →