Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.52 |
| ▸ | CTSS | P25774 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1231758 | 1.00 | CTSK (0.52) | CTSKCTSSMAPTATMCTSL | |
| SCHEMBL21219239 | 1.00 | CTSK (0.52) | CTSKCTSSMAPTATMCTSL | |
| Hydrochloric Acid SCHEMBL27316216 | 0.99 | CTSK (0.51) | CTSKCTSSMAPTATMCTSL | |
| SCHEMBL24876855 | 0.92 | CTSK (0.50) | CTSKCTSSMAPTATMCTSL | |
| Acetic Acid SCHEMBL1643722 | 0.89 | CTSK (0.52) | CTSKCTSSMAPTATMCTSL | |
| SCHEMBL118081 | 0.88 | CTSK (0.54) | CTSKCTSSMAPTATMCTSL | |
| SCHEMBL14923573 | 0.88 | CTSK (0.54) | CTSKCTSSMAPTATMCTSL | |
| SCHEMBL3755737 | 0.88 | CTSK (0.54) | CTSKCTSSMAPTATMCTSL | |
| SCHEMBL27351561 | 0.88 | CTSK (0.49) | CTSKCTSSATM | |
| SCHEMBL4583120 | 0.87 | CTSK (0.53) | CTSKCTSSMAPTATMCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | CTSK 2557/4885CTSS 1322/4885MAPT 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.