Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12166759 | 1.00 | SHBG (0.36) | SHBGTSHRKDM4ELMNACYP2C19 | |
| SCHEMBL21961611 | 0.85 | — | — | |
| SCHEMBL25642149 | 0.80 | SHBG (0.33) | SHBG | |
| SCHEMBL21334170 | 0.77 | GAA (0.35) | SHBG | |
| SCHEMBL1270265 | 0.76 | KDM4E (0.32) | KDM4ELMNACYP2C19 | |
| SCHEMBL43059 | 0.76 | SHBG (0.37) | SHBGTSHR | |
| SCHEMBL8779738 | 0.75 | — | — | |
| SCHEMBL24800555 | 0.74 | KDM4E (0.31) | KDM4ELMNACYP2C19 | |
| SCHEMBL18595246 | 0.74 | SHBG (0.36) | SHBGTSHR | |
| SCHEMBL760606 | 0.74 | SHBG (0.36) | SHBGTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2663312-A1 | IRAK INHIBITORS AND USES THEREOF | Nimbus Iris, Inc. (US) | 2013-11-20 | — | — | EP | disclosed |
| WO-2012097013-A1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS, INC. (US) | 2012-07-19 | — | — | WO | disclosed |