SHBG

Sex hormone-binding globulin · P04278 · SHBG on Sugi Atlas →

90,367 patent compounds predicted against SHBG, 67,033 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Methyltestosterone (SCHEMBL18657)	1.00	9/20
Etonogestrel (SCHEMBL117703)	1.00	9/20
Desogestrel (SCHEMBL41341)	1.00	8/20
Ethisterone (SCHEMBL24475)	1.00	7/20
Cortodoxone (SCHEMBL42590)	1.00	7/20
SCHEMBL26178	0.69	7/20
Algestone Acetonide (SCHEMBL42582)	0.60	7/20
Nootkatone (SCHEMBL110855)	0.37	7/20
Calusterone (SCHEMBL4509)	1.00	6/20
Hydroxyprogesterone (SCHEMBL8068)	1.00	6/20
Stanolone (SCHEMBL15163)	1.00	6/20
Stanolone (SCHEMBL27379)	1.00	6/20
SCHEMBL138937	1.00	6/20
SCHEMBL142941	1.00	6/20
Bolasterone (SCHEMBL145066)	1.00	6/20
Clostebol (SCHEMBL146712)	0.76	6/20
Topterone (SCHEMBL140769)	0.71	6/20
Guggulsterone (SCHEMBL141657)	0.64	6/20
Rosterolone (SCHEMBL141283)	0.57	6/20
Testosterone (SCHEMBL8452)	1.00	5/20

Clinical trials — most relevant to SHBG by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot)	PHASE4	COMPLETED
Testosterone for HIV-Positive Men With Reduced Serum Testosterone Levels and Abdominal Fat	PHASE4	COMPLETED
The Clinical Trial of Acupuncture Pre-treatment on PCOS	PHASE3	COMPLETED
Time to Eugonadal Range, Time to Steady State and Drying Time	PHASE3	COMPLETED
Testosterone and Physical Function in HIV+ Men	PHASE2	COMPLETED
Testosterone and Neural Function	EARLY_PHASE1	RECRUITING
Potential Effect of Dialyzer Leaching of BPA From the Fresenius Optiflux 160NR Compared to the Nipro ELISIO-15H	nan	COMPLETED
Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Aromatase Inhibitor Therapy	nan	COMPLETED
Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism	nan	WITHDRAWN
Warfarin Effects on Male Fertility After Cardiac Surgery	nan	NOT_YET_RECRUITING
BRCA Main Home Nutritional Intervention-random Study	nan	UNKNOWN
Aromatase Inhibitor Clinical Trial	nan	UNKNOWN
Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment	nan	COMPLETED
Development and Validation of in Vitro Cell-based Bioassays for Nuclear Receptor Activation	nan	COMPLETED
CBG Normalization After Discontinuation of COC's	nan	COMPLETED
Effect of a Low-Calorie Diet and/or Exercise Program on Risk Factors for Developing Breast Cancer in Overweight or Obese Postmenopausal Women	nan	COMPLETED
Neuropeptide Expression During the Ovarian Cycle and in Patients With PCOS	nan	UNKNOWN
Mass Spectrometry Based Cutoffs for Cortisol After Stimulation Tests	nan	COMPLETED
Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.	nan	RECRUITING
Effects of Testosterone and Fat Utilization	nan	COMPLETED
Comparison of Salivary and Serum Free Testosterone in Normal and Hypogonadal Men	nan	UNKNOWN
Effects of Hormonal Anabolic Deficiency and Neurovascular Alterations on Mortality in Male Patients With Heart Failure	nan	COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Dietary Fat, Eicosanoids and Breast Cancer Risk	nan	COMPLETED
SIBlos EXtension Study (SIBEX)	nan	COMPLETED
Endogenous Estrogen and Coronary Heart Disease in Women	nan	COMPLETED
Bone Disease in Chronic Pancreatitis: A Complex Phenomenon	nan	COMPLETED
Sex Hormone Binding Globulin, Testosterone and Glycemic Control in Patients With Type 2 Diabetes	nan	COMPLETED
Vitamin D and the Free Hormone Hypothesis	nan	COMPLETED
Acute Vitamin D Supplementation on Testosterone in Females	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a SHBG binder may also engage these)

Protein	Name	Similarity
A0EQL2	—	1.000	A0EQL2 →
P15196	—	1.000	P15196 →
Q62588	—	0.990	Q62588 →
P97497	—	0.988	P97497 →
P08689	—	0.987	P08689 →
O70540	—	0.969	O70540 →
Q96A99	—	0.969	Q96A99 →
P18627	—	0.968	P18627 →
MPL	Thrombopoietin receptor	0.966	landscape →
Q61790	—	0.966	Q61790 →
Q61826	—	0.966	Q61826 →
Q14773	—	0.964	Q14773 →
Q5BK54	—	0.964	Q5BK54 →
CSF3R	Granulocyte colony-stimulating factor receptor	0.963	landscape →
Q6UWB1	—	0.963	Q6UWB1 →
P60882	—	0.963	P60882 →
O95866	—	0.963	O95866 →
Q08351	—	0.963	Q08351 →
Q8NAC3	—	0.963	Q8NAC3 →
Q63191	—	0.962	Q63191 →
O75888	—	0.962	O75888 →
Q5TM20	—	0.962	Q5TM20 →
Q8K4C2	—	0.962	Q8K4C2 →
Q5NKT8	—	0.962	Q5NKT8 →
Q04997	—	0.961	Q04997 →
P0C6B3	—	0.961	P0C6B3 →
A5PJC7	—	0.961	A5PJC7 →
Q9HBX8	—	0.961	Q9HBX8 →
O15533	—	0.961	O15533 →
Q8VCM2	—	0.961	Q8VCM2 →