SCHEMBL10325919

SCHEMBL10325919

CCCN(CCC)C(=O)C1=Cc2cc(-c3ccc(C(=O)N4CCCC4)cc3)ccc2N=C(N)C1

nearest known ligand 0.86

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 20/20 0.86
TLR7 Q9NYK1 14/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Motolimod SCHEMBL254984 0.93 TLR8 (1.00) TLR8TLR7
Motolimod SCHEMBL29353690 0.93 TLR8 (1.00) TLR8TLR7
SCHEMBL1803349 0.92 TLR8 (0.98) TLR8TLR7
SCHEMBL18563909 0.92 TLR8 (0.73) TLR8TLR7
SCHEMBL26080080 0.90 TLR8 (0.95) TLR8TLR7
SCHEMBL1801525 0.89 TLR8 (0.93) TLR8TLR7
SCHEMBL18772046 0.89 TLR8 (0.93) TLR8TLR7
SCHEMBL1238499 0.89 TLR8 (0.92) TLR8TLR7
SCHEMBL1801811 0.88 TLR8 (0.90) TLR8TLR7
SCHEMBL15625316 0.88 TLR8 (0.78) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240016813-A1 METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION Accencio LLC 2024-01-18 US disclosed
US-20240016813-A1 METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION Accencio LLC 2024-01-18 US disclosed
US-11702476-B2 Anti-EGFR combinations for treating tumors BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2023-07-18 US disclosed
EP-3166640-B1 COMBINATION THERAPY COMPOSITIONS AND METHODS FOR TREATING CANCERS BIRDIE BIOPHARMACEUTICALS INC (KY) 2023-06-14 EP disclosed
EP-4001311-A1 ANTI-PD-L1 COMBINATIONS FOR TREATING TUMORS Birdie Biopharmaceuticals Inc. (KY) 2022-05-25 EP disclosed
EP-3166976-B1 ANTI-PD-L1 COMBINATIONS FOR TREATING TUMORS BIRDIE BIOPHARMACEUTICALS INC (KY) 2022-02-23 EP disclosed
US-20210347911-A1 ANTI-HER2 COMBINATIONS FOR TREATING TUMORS BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2021-11-11 US disclosed
US-20170290923-A1 Anti PD-L1 Conjugates for Treating Tumors BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2017-10-12 US disclosed
EP-3208263-A1 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VentiRx Pharmaceuticals, Inc. (US) 2017-08-23 EP disclosed
US-9718796-B2 Substituted benzoazepines as toll-like receptor modulators VENTIRX PHARMACEUTICALS, INC. (US) 2017-08-01 US disclosed
EP-2663550-B1 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VENTIRX PHARMACEUTICALS INC (US) 2016-12-14 EP disclosed
WO-2016004875-A1 COMBINATION THERAPY COMPOSITIONS AND METHODS FOR TREATING CANCERS SHANGHAI BIRDIE BIOTECH, INC. (CN) 2016-01-14 WO disclosed
WO-2016004876-A1 ANTI-PD-L1 COMBINATIONS FOR TREATING TUMORS SHANGHAI BIRDIE BIOTECH, INC. (CN) 2016-01-14 WO disclosed
US-20140088085-A1 Substituted Benzoazepines As Toll-Like Receptor Modulators ARRAY BIOPHARMA, INC (US) 2014-03-27 US disclosed
US-20140088085-A1 Substituted Benzoazepines As Toll-Like Receptor Modulators ARRAY BIOPHARMA, INC (US) 2014-03-27 US disclosed
US-20140066432-A1 Substituted Benzoazepines As Toll-Like Receptor Modulators VENTIRX PHARMACEUTICALS, INC. 2014-03-06 US disclosed
US-20140066432-A1 Substituted Benzoazepines As Toll-Like Receptor Modulators VENTIRX PHARMACEUTICALS, INC. 2014-03-06 US disclosed
US-20140066432-A1 Substituted Benzoazepines As Toll-Like Receptor Modulators VENTIRX PHARMACEUTICALS, INC. 2014-03-06 US disclosed
EP-2663550-A2 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VentiRx Pharmaceuticals, Inc. (US) 2013-11-20 EP disclosed
WO-2012097173-A2 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VENTIRX PHARMACEUTICALS, INC. (US) 2012-07-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11702476-B2 Anti-EGFR combinations for treating tumors EGFR, ERBB3, ERBB2 TLR8 1153/4885TLR7 2007/4885
US-20140066432-A1 Substituted Benzoazepines As Toll-Like Receptor Modulators TLR8, TLR9, TLR1 TLR8 1/4885TLR7 4/4885
US-20210347911-A1 ANTI-HER2 COMBINATIONS FOR TREATING TUMORS ERBB2, EGFR, ERBB3 TLR8 900/4885TLR7 1770/4885
US-20240016813-A1 METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION ACE2, ACE, TMPRSS2 TLR8 878/4885TLR7 1436/4885
US-20140088085-A1 Substituted Benzoazepines As Toll-Like Receptor Modulators TLR8, TLR9, TLR1 TLR8 1/4885TLR7 4/4885
US-20170290923-A1 Anti PD-L1 Conjugates for Treating Tumors CD274, PDCD1LG2, PDCD1 TLR8 901/4885TLR7 980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.