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TLR1

Toll-like receptor 1 · Q15399 · TLR1 on Sugi Atlas →

11,947 patent compounds predicted against TLR1, 7,518 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL870999 SCHEMBL870999 0.61 18/20
SCHEMBL1620708 SCHEMBL1620708 0.43 15/20
SCHEMBL1620710 SCHEMBL1620710 0.43 15/20
SCHEMBL2393290 SCHEMBL2393290 0.41 13/20
Rolicyprine Rolicyprine (SCHEMBL49385) 0.51 12/20
SCHEMBL2016541 SCHEMBL2016541 0.47 11/20
SCHEMBL1574619 SCHEMBL1574619 0.43 8/20
SCHEMBL1260380 SCHEMBL1260380 0.65 7/20
SCHEMBL1937652 SCHEMBL1937652 0.53 7/20
SCHEMBL1969458 SCHEMBL1969458 0.43 7/20
SCHEMBL1197464 SCHEMBL1197464 0.52 5/20
SCHEMBL1197465 SCHEMBL1197465 0.52 5/20
SCHEMBL1617550 SCHEMBL1617550 0.46 4/20
SCHEMBL1777642 SCHEMBL1777642 0.35 4/20
SCHEMBL1777643 SCHEMBL1777643 0.35 4/20
SCHEMBL1777542 SCHEMBL1777542 0.32 4/20
SCHEMBL1777544 SCHEMBL1777544 0.32 4/20
SCHEMBL1777546 SCHEMBL1777546 0.32 4/20
SCHEMBL529661 SCHEMBL529661 0.56 3/20
SCHEMBL529662 SCHEMBL529662 0.56 3/20

Clinical trials — most relevant to TLR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar PHASE2/PHASE3UNKNOWN
Reducing Abundance of Human Papilloma Virus in Women by Taking Probiotic PHASE2/PHASE3WITHDRAWN
Use of Presepsin as a Marker for Immunotherapy Administration in Pneumonia PHASE2COMPLETED
Toll-like Receptor (TLR) Ligand Matured Dendritic Cell Vaccination in Melanoma Patients PHASE1/PHASE2COMPLETED
Single-step Antigen Loading and TLR Activation of Dendritic Cells in Melanoma Patients PHASE1/PHASE2COMPLETED
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19 PHASE2UNKNOWN
Safety/Efficacy Study of Bovine Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis PHASE2COMPLETED
The Effects of GLA on Human Volunteers PHASE1COMPLETED
Personalized Multi-peptide Vaccination in CLL Patients PHASE1COMPLETED
An Investigation of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2245035 in Healthy Volunteers and Allergic Rhinitics. PHASE1COMPLETED
Role of TLR4 in Environmental Asthma PHASE1COMPLETED
Bacteremia in Intensive Care Unit (ICU) nanUNKNOWN
Impact of Nasal Saline Irrigations on Viral Load in Patients With COVID-19 nanCOMPLETED
Expression of Toll-like Receptors 3 , 7 and 9 in Peripheral Blood Mononuclear Cells of COVID-19 Patients nanUNKNOWN
Efficacy of Intranasal Probiotic Treatment to Reduce Severity of Symptoms in COVID19 Infection nanCOMPLETED
MicroRNAs and Cytokines in Peri-Implantitis Tissue nanUNKNOWN
Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis nanCOMPLETED
The Role of Neutrophil CD64 and Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Neonatal Sepsis nanUNKNOWN
Deep Phenotyping of Cutaneous Lupus Erythematosus nanUNKNOWN
Neuro-Immune Interactions in the Gut nanCOMPLETED
Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis nanUNKNOWN
TLR4 Polymorphisms and Risk of Skin Cancer nanCOMPLETED
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
Innate Immune Response in COPD nanCOMPLETED
TLR 9 (rs352140) Gene Polymorphism in Helicobacter Pylori Infection nanCOMPLETED
X-linked Biological Response to HIV Sensing: the ANRS EP 53 Study nanCOMPLETED
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population nanRECRUITING
Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans nanCOMPLETED
The Suppression of Toll Like Receptors by Insulin nanCOMPLETED
Establishing a Diagnostic Test for Non-tuberculous Mycobacteria Lung Infection Using Non-tuberculous Mycobacteria Antigen Stimulation Test: From Immune Base, Standardized Setup to Validation nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a TLR1 binder may also engage these)

ProteinNameSimilarity
Q0ZUL9 — 1.000 Q0ZUL9 →
Q9EPQ1 — 0.995 Q9EPQ1 →
Q9EPW9 — 0.993 Q9EPW9 →
Q704V6 — 0.992 Q704V6 →
TLR6 Toll-like receptor 6 0.991 landscape →
Q9DD78 — 0.987 Q9DD78 →
B5T267 — 0.987 B5T267 →
Q95M53 — 0.987 Q95M53 →
Q6T752 — 0.986 Q6T752 →
B2LT61 — 0.986 B2LT61 →
B3Y618 — 0.985 B3Y618 →
Q6GV17 — 0.984 Q6GV17 →
Q689D1 — 0.984 Q689D1 →
TLR2 Toll-like receptor 2 0.983 landscape →
Q95LA9 — 0.983 Q95LA9 →
Q2V897 — 0.983 Q2V897 →
Q9BXR5 — 0.983 Q9BXR5 →
Q2PZH4 — 0.983 Q2PZH4 →
B3Y615 — 0.983 B3Y615 →
B3Y614 — 0.982 B3Y614 →
Q0GC71 — 0.982 Q0GC71 →
B2LT64 — 0.981 B2LT64 →
B3Y613 — 0.980 B3Y613 →
B2LT62 — 0.980 B2LT62 →
B2LT65 — 0.976 B2LT65 →
TLR7 Toll-like receptor 7 0.976 landscape →
Q9R1F8 — 0.974 Q9R1F8 →
P58681 — 0.973 P58681 →
Q9QUN7 — 0.973 Q9QUN7 →
Q6R6L8 — 0.962 Q6R6L8 →