Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PRKACG | P22612 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9910342 | 0.86 | MET (0.72) | METCYP3A4PRKACG | |
| SCHEMBL2706018 | 0.83 | MET (1.00) | METCYP3A4PRKACG | |
| SCHEMBL2700783 | 0.80 | MET (0.74) | METCYP3A4PRKACG | |
| SCHEMBL18231496 | 0.78 | MET (0.60) | MET | |
| SCHEMBL9910309 | 0.72 | MET (0.75) | MET | |
| SCHEMBL9910317 | 0.71 | MET (0.79) | METCYP3A4PRKACG | |
| SCHEMBL9924353 | 0.71 | MET (0.66) | METCYP3A4PRKACG | |
| SCHEMBL2697982 | 0.71 | MET (0.77) | METCYP3A4PRKACG | |
| SCHEMBL9910328 | 0.71 | MET (0.75) | METCYP3A4PRKACG | |
| SCHEMBL9910298 | 0.71 | MET (0.79) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217177-B2 | Fused heterocyclic derivatives and methods of use | AMGEN INC. (US) | 2012-07-10 | — | — | US | disclosed |